product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SB 269970 hydrochloride
catalog :
1612
quantity :
10 mg (also 50 mg)
price :
225 USD
more info or order :
citations: 20
Reference |
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Gautam J, Banskota S, Regmi S, Ahn S, Jeon Y, Jeong H, et al. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 2016;15:75 pubmed
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Madden C, Morrison S. Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cord. Neuropharmacology. 2008;54:487-96 pubmed
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Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed
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product information
brand :
Tocris
master code :
1612
SKU :
1612/10
product name :
SB 269970 hydrochloride
description :
Potent and selective 5-HT7 antagonist; brain penetrant
target :
5-HT7 Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
388.95
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective 5-HT7 receptor antagonist (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B and 6.0 for 5-HT1A, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4 and 5-HT6 receptors respectively). Brain penetrant in vivo .
catalog number base :
1612
product keywords :
Potent selective 5-HT7 antagonists Brain penetrant Serotonin Receptors 5-Hydroxytryptamine SB269970 hydrochloride GlaxoSmithKline GSK 5-HT7 Receptors 1612,
extended description :
Potent and selective 5-HT7 antagonist; brain penetrant
chemical name text :
(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
formula :
C 18 H 28 N 2 O 3 S.HCl
formula text :
C18H28N2O3S.HCl
cas num :
261901-57-9
2020 USD :
214
2021 USD :
225 USD
storage :
Store at +4°C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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