SB 269970 hydrochloride | Tocris Bioscience 1612/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 269970 hydrochloride

catalog :

1612/10

quantity :

10 mg (also 50 mg)

price :

296 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
Tang H, Zhang Y, Yang L, Hong C, Chen K, Li Y, et al. Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways. FASEB J. 2023;37:e22893 pubmed publisher
Nguyen H, Cho D, Jang S, Han S, Park S. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol. 2019;23:271-279 pubmed publisher
Kwon Y, Wang H, Denou E, Ghia J, Rossi L, Fontes M, et al. Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis. Cell Mol Gastroenterol Hepatol. 2019;7:709-728 pubmed publisher
Bijata M, Labus J, Guseva D, Stawarski M, Butzlaff M, Dzwonek J, et al. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix. Cell Rep. 2017;19:1767-1782 pubmed publisher
Speranza L, Labus J, Volpicelli F, Guseva D, Lacivita E, Leopoldo M, et al. Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons. J Neurochem. 2017;141:647-661 pubmed publisher
Gautam J, Banskota S, Regmi S, Ahn S, Jeon Y, Jeong H, et al. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 2016;15:75 pubmed
Yin L, Rasch M, He Q, Wu S, Dou F, Shu Y. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex. 2017;27:509-521 pubmed publisher
Chien C, Su M. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. J Biomed Sci. 2015;22:42 pubmed publisher
Speranza L, Giuliano T, Volpicelli F, De Stefano M, Lombardi L, Chambery A, et al. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Front Behav Neurosci. 2015;9:62 pubmed publisher
Watts S, Darios E, Seitz B, Thompson J. 5-HT is a potent relaxant in rat superior mesenteric veins. Pharmacol Res Perspect. 2015;3:e00103 pubmed publisher
Watanabe H, Saito R, Nakano T, Takahashi H, Takahashi Y, Sumiyoshi K, et al. Effect of peripheral 5-HT on glucose and lipid metabolism in wether sheep. PLoS ONE. 2014;9:e88058 pubmed publisher
Corcoran A, Commons K, Wu Y, Smith J, Harris M, Richerson G. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. J Neurosci. 2014;34:51-9 pubmed publisher
Nikiforuk A, Kos T, Fijał K, Hołuj M, Rafa D, Popik P. Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats. PLoS ONE. 2013;8:e66695 pubmed publisher
Kim J, Bridle B, Ghia J, Wang H, Syed S, Manocha M, et al. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J Immunol. 2013;190:4795-804 pubmed publisher
Soll C, Riener M, Oberkofler C, Hellerbrand C, Wild P, DeOliveira M, et al. Expression of serotonin receptors in human hepatocellular cancer. Clin Cancer Res. 2012;18:5902-10 pubmed publisher
Bonaventure P, Aluisio L, Shoblock J, Boggs J, Fraser I, Lord B, et al. Pharmacological blockade of serotonin 5-HT? receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. PLoS ONE. 2011;6:e20210 pubmed publisher
Manzke T, Dutschmann M, Schlaf G, Mörschel M, Koch U, Ponimaskin E, et al. Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci. 2009;364:2589-602 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher
Huang C, Liang Y, Lee C, Wu M, Hsu K. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology. 2009;34:1979-92 pubmed publisher
Madden C, Morrison S. Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cord. Neuropharmacology. 2008;54:487-96 pubmed
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1612

SKU :

1612/10

product name :

SB 269970 hydrochloride

description :

Potent and selective 5-HT7 antagonist; brain penetrant

target :

5-HT7 Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

388.95

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 269970 hydrochloride is a potent and selective 5-HT7 receptor antagonist (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B and 6.0 for 5-HT1A, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4 and 5-HT6 receptors respectively). Brain penetrant in vivo .

product keywords :

Potent selective 5-HT7 antagonists Brain penetrant Serotonin Receptors 5-Hydroxytryptamine SB269970 hydrochloride GlaxoSmithKline GSK 5-HT7 Receptors 1612,

extended description :

Potent and selective 5-HT7 antagonist; brain penetrant

chemical name text :

(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride

formula :

C18H28N2O3S.HCl

formula text :

C18H28N2O3S.HCl

cas num :

261901-57-9

USD :

284

USD 2025 :

296 USD

product details :

Potent and selective 5-HT7 antagonist; brain penetrant

more info or order :

Tocris Bioscience product webpage