Rottlerin | Tocris Bioscience 1610 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Rottlerin

catalog :

1610

quantity :

50 mg

price :

402 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Pietras E, Mirantes Barbeito C, Fong S, Loeffler D, Kovtonyuk L, Zhang S, et al. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nat Cell Biol. 2016;18:607-18 pubmed publisher
Shu Q, Hu Z, Huang C, Yu X, Fan H, Yang J, et al. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS ONE. 2014;9:e95259 pubmed publisher
Goldklang M, Perez Zoghbi J, Trischler J, Nkyimbeng T, Zakharov S, Shiomi T, et al. Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. FASEB J. 2013;27:4975-86 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Barbaric I, Jones M, Harley D, Gokhale P, Andrews P. High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival. J Biomol Screen. 2011;16:603-17 pubmed publisher
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz Sanjuan I, Pacifici R, et al. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen. 2010;15:478-87 pubmed publisher

product information

brand :

Tocris

master code :

1610

SKU :

1610/50

product name :

Rottlerin

description :

Reported PKC inhibitor

target :

Protein Kinase C Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

95%

observed molecular weight :

516.55

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 u M respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.

catalog number base :

1610

product keywords :

Reported PKCdelta inhibitors inhibits Protein Kinases C Protein Kinase C Autophagy 1610,

extended description :

Reported PKC inhibitor

chemical name text :

3 -[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2 ,4 ,6 -trihydroxy-5 -methylacetophenone

formula :

C 30 H 28 O 8

formula text :

C30H28O8

cas num :

82-08-6

2020 USD :

390

2021 USD :

402 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage