NKH 477 | Tocris Bioscience 1603 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NKH 477

catalog :

1603

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Frieling J, Shay G, Izumi V, Aherne S, Saul R, Budzevich M, et al. Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP1-17. Oncogene. 2017;36:4498-4507 pubmed publisher
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher
Muschter D, SchÃ¤fer N, Stangl H, Straub R, GrÃ¤ssel S. Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis. PLoS ONE. 2015;10:e0139726 pubmed publisher
Brosnahan A, Vulchanova L, Witta S, Dai Y, Jones B, Brown D. Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells. J Neuroimmunol. 2013;259:8-16 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
Zhong P, Wang W, Yu F, Nazari M, Liu X, Liu Q. Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology. 2012;37:2377-87 pubmed publisher
Xia M, Guo V, Huang R, Shahane S, Austin C, Nirenberg M, et al. Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. Cell Mol Neurobiol. 2011;31:901-7 pubmed publisher

product information

brand :

Tocris

master code :

1603

SKU :

1603/10

product name :

NKH 477

description :

Water-soluble adenylyl cyclase activator

target :

Adenylyl Cyclase Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

546.1

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Water-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo .

catalog number base :

1603

product keywords :

Water-soluble adenylyl adenylate cyclases activators cAMP NKH477 Colforsin dapropate hydrochloride 6-(3-dimethylaminopropionyl)forskolin hydrochloride Adenylyl Cyclase Enzyme Substrates/ Activators 1603,

extended description :

Water-soluble adenylyl cyclase activator

chemical name text :

N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester -alanine hydrochloride

formula :

C 27 H 43 NO 8 .HCl

formula text :

C27H43NO8.HCl

cas num :

138605-00-2

2020 USD :

214

2021 USD :

219 USD

alt names :

Colforsin dapropate hydrochloride, 6-(3-dimethylaminopropionyl)forskolin hydrochloride

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage