product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
NBI 27914 hydrochloride
catalog :
1591/10
quantity :
10 mg (also 50 mg)
price :
219 USD
more info or order :
citations: 12
Reference
Rajbhandari A, Baldo B, Bakshi V. Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities. J Neurosci. 2015;35:14270-85 pubmed publisher
Navarro G, Quiroz C, Moreno Delgado D, Sierakowiak A, McDowell K, Moreno E, et al. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. J Neurosci. 2015;35:6639-53 pubmed publisher
Jia F, Li X, Li T, Wu J, Xie B, Lin L. Role of nesfatin-1 in a rat model of visceral hypersensitivity. World J Gastroenterol. 2013;19:3487-93 pubmed publisher
Silberman Y, Winder D. Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology. 2013;70:316-23 pubmed publisher
Ji G, Fu Y, Adwanikar H, Neugebauer V. Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses. Mol Pain. 2013;9:2 pubmed publisher
Lowery Gionta E, Navarro M, Li C, Pleil K, Rinker J, Cox B, et al. Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci. 2012;32:3405-13 pubmed publisher
Wang L, Million M, Rivier J, Rivier C, Craft N, Stenzel Poore M, et al. CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice. PLoS ONE. 2011;6:e16377 pubmed publisher
Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, et al. NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. Mol Brain. 2010;3:37 pubmed publisher
Liu S, Ren W, Qu M, Bishop G, Wang G, Wang X, et al. Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon. Br J Pharmacol. 2010;159:222-36 pubmed publisher
Nakamura T, Sapru H. Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. Am J Physiol Heart Circ Physiol. 2009;296:H2022-9 pubmed publisher
Gutknecht E, Hauger R, Van der Linden I, Vauquelin G, Dautzenberg F. Expression, binding, and signaling properties of CRF2(a) receptors endogenously expressed in human retinoblastoma Y79 cells: passage-dependent regulation of functional receptors. J Neurochem. 2008;104:926-36 pubmed
Gallopin T, Geoffroy H, Rossier J, Lambolez B. Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. Cereb Cortex. 2006;16:1440-52 pubmed
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1591
SKU :
1591/10
product name :
NBI 27914 hydrochloride
description :
Selective non-peptide CRF1 antagonist
target :
CRF1 Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Store at RT
observed molecular weight :
470.66
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonist (Ki = 1.7 nM); has no activity at CRF2 receptors. Blocks behavioral seizures in vivo .
product keywords :
Selective non-peptide CRF1 antagonists Corticotropin-Releasing Factor1 Receptors NBI27914 hydrochloride CRF1 Receptors 1591,
extended description :
Selective non-peptide CRF1 antagonist
chemical name text :
5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N -(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
formula :
C18H20Cl4N4.HCl
formula text :
C18H20Cl4N4.HCl
cas num :
1215766-76-9
USD :
216
USD 2025 :
219 USD
product details :
Selective non-peptide CRF1 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK