Ro 32-0432 hydrochloride | Tocris Bioscience 1587/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 32-0432 hydrochloride

catalog :

1587/1

quantity :

1 mg

price :

278 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Signore M, Pelacchi F, Di Martino S, Runci D, Biffoni M, Giannetti S, et al. Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis. 2014;5:e1223 pubmed publisher
Robert G, Ben Sahra I, Puissant A, Colosetti P, Belhacene N, Gounon P, et al. Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS ONE. 2009;4:e7889 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1587

SKU :

1587/1

product name :

Ro 32-0432 hydrochloride

description :

Potent, orally active PKC inhibitor

target :

Protein Kinase C Inhibitors

unit size :

1 mg

category :

Small Molecules

purity :

99%

storage :

Store at -20°C

observed molecular weight :

489.01

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC s , , , and respectively. Orally available and prevents T cell chronic inflammation in vivo .

product keywords :

Potent orally active PKC inhibitors inhibits Protein Kinases C Ro32-0432 hydrochloride Protein Kinase C 1587,

extended description :

Potent, orally active PKC inhibitor

chemical name text :

3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride

formula :

C28H28N4O2.HCl

formula text :

C28H28N4O2.HCl

cas num :

1781828-85-0

USD :

275

USD 2025 :

278 USD

product details :

Potent, orally active PKC inhibitor

more info or order :

Tocris Bioscience product webpage