SKF 83566 hydrobromide | Tocris Bioscience 1586 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SKF 83566 hydrobromide

catalog :

1586

quantity :

10 mg (also 50 mg)

price :

115 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Leng Z, Lin S, Wu Z, Guo Y, Cai L, Shang H, et al. Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. Autophagy. 2017;13:1404-1419 pubmed publisher
Li Y, Chen X, Dzakpasu R, Conant K. Dopamine-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons. J Neurochem. 2017;140:550-560 pubmed publisher
Xing L, McDonald H, Da Fonte D, Gutierrez Villagomez J, Trudeau V. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Front Neurosci. 2015;9:310 pubmed publisher
Savalli G, Bashir Z, Warburton E. Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory. Learn Mem. 2015;22:69-73 pubmed publisher
Cassar M, Issa A, Riemensperger T, Petitgas C, Rival T, Coulom H, et al. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum Mol Genet. 2015;24:197-212 pubmed publisher
Huang Y, Levine A, Kandel D, Yin D, Colnaghi L, Drisaldi B, et al. D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus. Learn Mem. 2014;21:153-60 pubmed publisher
Billes S, Simonds S, Cowley M. Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism. Mol Metab. 2012;1:86-93 pubmed publisher
Belinsky G, Sirois C, Rich M, Short S, Moore A, Gilbert S, et al. Dopamine receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev. 2013;22:1522-40 pubmed publisher
Stramiello M, Wagner J. D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology. 2008;55:871-7 pubmed publisher
Liu T, Dartevelle L, Yuan C, Wei H, Wang Y, Ferveur J, et al. Increased dopamine level enhances male-male courtship in Drosophila. J Neurosci. 2008;28:5539-46 pubmed publisher

product information

brand :

Tocris

master code :

1586

SKU :

1586/10

product name :

SKF 83566 hydrobromide

description :

Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2

target :

Dopamine D1 and D5 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

413.15

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 u M for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo .

catalog number base :

1586

product keywords :

Potent selective D1-like antagonists Dopamine Receptors D5 dopaminergic SKF83566 hydrobromide D1 and D5 Receptors Adenylyl Cyclase 1586,

extended description :

Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2

chemical name text :

8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide

formula :

C 17 H 18 BrNO.HBr

formula text :

C17H18BrNO.HBr

cas num :

108179-91-5

2020 USD :

110

2021 USD :

115 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage