product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
MRS 1706
catalog :
1584
quantity :
10 mg (also 50 mg)
price :
189 USD
more info or order :
citations: 14
Reference
Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, et al. Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine. 2018;32:72-83 pubmed publisher
Wakisaka N, Miyasaka N, Koide T, Masuda M, Hiraki Kajiyama T, Yoshihara Y. An Adenosine Receptor for Olfaction in Fish. Curr Biol. 2017;27:1437-1447.e4 pubmed publisher
Eusemann T, Willmroth F, Fiebich B, Biber K, van Calker D. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS ONE. 2015;10:e0134934 pubmed publisher
Li H, Chuang A, O BRIEN J. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci. 2014;31:237-43 pubmed publisher
Rizvi Y, Mehta C, Oyekan A. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol. 2013;59:144-51 pubmed publisher
Lee S, Kim J, Kim J, Jang Y, Kim J, Park Y, et al. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. Korean J Anesthesiol. 2012;63:340-5 pubmed publisher
Long X, Mokelke E, Neeb Z, Alloosh M, Edwards J, Sturek M. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Pharmacol Exp Ther. 2010;335:781-7 pubmed publisher
Mandapathil M, Hilldorfer B, Szczepanski M, Czystowska M, Szajnik M, Ren J, et al. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem. 2010;285:7176-86 pubmed publisher
Clark B, Kurth Nelson Z, Newman E. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci. 2009;29:11237-45 pubmed publisher
Schneider D, Lindsay J, Zhou Y, Molina J, Blackburn M. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J. 2010;24:70-80 pubmed publisher
Xi J, McIntosh R, Shen X, Lee S, Chanoit G, Criswell H, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009;47:684-90 pubmed publisher
Epperson S, Brunton L, Ramirez Sanchez I, Villarreal F. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2009;296:C1171-7 pubmed publisher
Ryzhov S, Zaynagetdinov R, Goldstein A, Novitskiy S, Dikov M, Blackburn M, et al. Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. J Immunol. 2008;180:7212-20 pubmed
Newman E. Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci. 2005;25:5502-10 pubmed
product information
brand :
Tocris
master code :
1584
SKU :
1584/10
product name :
MRS 1706
description :
Potent and selective A2B inverse agonist
target :
Adenosine A3 Receptor Inverse Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
96%
observed molecular weight :
503.56
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).
catalog number base :
1584
product keywords :
Potent selective A2B inverse agonists Receptors adenosines MRS1706 Adenosine A2B Receptors 1584,
extended description :
Potent and selective A2B inverse agonist
chemical name text :
N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
formula :
C 27 H 29 N 5 O 5
formula text :
C27H29N5O5
cas num :
264622-53-9
2020 USD :
185
2021 USD :
189 USD
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK