Purvalanol B | Tocris Bioscience 1581/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Purvalanol B

catalog :

1581/10

quantity :

10 mg (also 50 mg)

price :

275 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ma X, Zhang L, Song J, Nguyen E, Lee R, Rodgers S, et al. Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation. Nat Commun. 2019;10:296 pubmed publisher
Schreiber T, Mäusbacher N, Keri G, Cox J, Daub H. An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics. 2010;9:1047-62 pubmed publisher
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Keri G, et al. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics. 2007;6:537-47 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1581

SKU :

1581/10

product name :

Purvalanol B

description :

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

target :

Cyclin-dependent Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

432.91

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Purvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC50 10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).

product keywords :

Cyclin-dependent protein kinases inhibitors inhibits Cdk PurvalanolB NG95 potent cdk1 cdk2 cdk5 selective antiproliferative apoptosis autophagy NG 95 Cyclin-dependent Kinase Non-selective CDKs 1581,

extended description :

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

chemical name text :

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

formula :

C20H25ClN6O3

formula text :

C20H25ClN6O3

cas num :

212844-54-7

USD :

272

USD 2025 :

275 USD

product details :

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

alt names :

NG 95

more info or order :

Tocris Bioscience product webpage