Purvalanol A | Tocris Bioscience 1580/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Purvalanol A

catalog :

1580/10

quantity :

10 mg (also 50 mg)

price :

255 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Karayel Ö, Sanal E, Giese S, Üretmen Kagıalı Z, Polat A, Hu C, et al. Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018;8:2269 pubmed publisher
Gayek A, Ohi R. CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. PLoS ONE. 2016;11:e0157491 pubmed publisher
Seldin L, Poulson N, Foote H, Lechler T. NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. Mol Biol Cell. 2013;24:3651-62 pubmed publisher
Origanti S, Cai S, Munir A, White L, Piwnica Worms H. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene. 2013;32:577-88 pubmed publisher
Fabritius A, Flynn J, McNally F. Initial diameter of the polar body contractile ring is minimized by the centralspindlin complex. Dev Biol. 2011;359:137-148 pubmed publisher
Rowe J, Greenblatt R, Liu D, Moffat J. Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice. Antiviral Res. 2010;86:276-85 pubmed publisher
Ozlu N, Monigatti F, Renard B, Field C, Steen H, Mitchison T, et al. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010;9:336-50 pubmed publisher
Pennati M, Campbell A, Curto M, Binda M, Cheng Y, Wang L, et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005;4:1328-37 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1580

SKU :

1580/10

product name :

Purvalanol A

description :

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

target :

Cyclin-dependent Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

388.9

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Purvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 4, 4 - 70, 75 - 240 and 100 nM for cdk1, cdk2, cdk5 and cdk 7, respectively). Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

product keywords :

Cyclin-dependent protein kinases inhibitors inhibits Cdk PurvalanolA NG60 NG 60 Cyclin-dependent Kinase Non-selective CDKs 1580,

extended description :

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

chemical name text :

(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

formula :

C19H25ClN6O

formula text :

C19H25ClN6O

cas num :

212844-53-6

USD :

252

USD 2025 :

255 USD

product details :

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

alt names :

NG 60

more info or order :

Tocris Bioscience product webpage