CTOP | Tocris Bioscience 1578 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CTOP

catalog :

1578

quantity :

1 mg

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Nam M, Han K, Lee J, Won W, Koh W, Bae J, et al. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Rep. 2019;28:1154-1166.e5 pubmed publisher
Dai W, Liu X, Bao Y, Yan B, Jiang N, Yu B, et al. Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med. 2018;50:148 pubmed publisher
Stoeber M, Jullié D, Lobingier B, Laeremans T, Steyaert J, Schiller P, et al. A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron. 2018;98:963-976.e5 pubmed publisher
FranÃ§ois A, Low S, Sypek E, Christensen A, Sotoudeh C, BEIER K, et al. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins. Neuron. 2017;93:822-839.e6 pubmed publisher
Gerhold K, Drdla Schutting R, Honsek S, Forsthuber L, SandkÃ¼hler J. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 2015;35:9580-94 pubmed publisher
Morse M, Sun H, Tran E, Levenson R, Fang Y. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 2013;14:17 pubmed publisher
Morse M, Tran E, Sun H, Levenson R, Fang Y. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS ONE. 2011;6:e25643 pubmed publisher
Beaudry H, Dubois D, Gendron L. Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. J Neurosci. 2011;31:13068-77 pubmed publisher
Choi C, Kim W, Lee H, Jeong C, Kim C, Lee S, et al. Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor. Korean J Pain. 2010;23:236-41 pubmed publisher
Gross G, Baker J, Hsu A, Wu H, Falck J, Nithipatikom K. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. Am J Physiol Heart Circ Physiol. 2010;298:H2201-7 pubmed publisher
Margolis E, Fields H, Hjelmstad G, Mitchell J. Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. J Neurosci. 2008;28:12672-81 pubmed publisher
Börner C, Hollt V, Kraus J. Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Pharmacol. 2006;69:1486-91 pubmed

product information

brand :

Tocris

master code :

1578

SKU :

1578/1

product name :

CTOP

description :

Potent and selective u antagonist

target :

mu Opioid Receptor Antagonists

category :

Peptides

unit size :

1 mg

observed molecular weight :

1062.28

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Potent and selective u opioid receptor antagonist (Ki values are 0.96 and 10,000 nM for u and receptors respectively). Causes behavioral effects on central administration in vivo . Also increases K+ currents in rat locus ceruleus neurons in vitro via a receptor independent mechanism.

catalog number base :

1578

product keywords :

selective potent -opioid mu-opioid antagonists MOP Receptors OP3 Mu Opioid Receptors 1578,

extended description :

Potent and selective u antagonist

formula :

C 50 H 67 N 11 O 11 S 2

formula text :

C50H67N11O11S2

cas num :

103429-31-8

2020 USD :

187

2021 USD :

195 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage