Cucurbitacin I | Tocris Bioscience 1571 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cucurbitacin I

catalog :

1571

quantity :

1 mg

price :

259 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Martin Gallausiaux C, Larraufie P, Jarry A, Béguet Crespel F, Marinelli L, Ledue F, et al. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol. 2018;9:2838 pubmed publisher
Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, et al. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene. 2016;35:5388-5399 pubmed publisher
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed publisher
Wan J, Zhao X, Vojtek A, Goldman D. Retinal injury, growth factors, and cytokines converge on Î²-catenin and pStat3 signaling to stimulate retina regeneration. Cell Rep. 2014;9:285-97 pubmed publisher
Stechishin O, Luchman H, Ruan Y, Blough M, Nguyen S, Kelly J, et al. On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Neuro Oncol. 2013;15:198-207 pubmed publisher
Hamilton K, Simmons J, Ding S, Van Landeghem L, Lund P. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Mol Cancer Res. 2011;9:1718-31 pubmed publisher
Tiffon C, Adams J, van der Fits L, Wen S, Townsend P, Ganesan A, et al. The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells. Br J Pharmacol. 2011;162:1590-602 pubmed publisher
Bonifazi P, Zelante T, D Angelo C, De Luca A, Moretti S, Bozza S, et al. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol. 2009;2:362-74 pubmed publisher

product information

brand :

Tocris

master code :

1571

SKU :

1571/1

product name :

Cucurbitacin I

description :

Selective inhibitor of STAT3/JAK2 signaling

target :

JAK Kinase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

95%

observed molecular weight :

514.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

catalog number base :

1571

product keywords :

Selective inhibitors inhibits STAT3/JAK2 signaling signalling Janus Activated Kinase JAK Kinases Signal Transducers activators Transcription STAT CucurbitacinI ElatericinB JSI124 Elatericin B JSI 124 JAK Kinase STAT 1571,

extended description :

Selective inhibitor of STAT3/JAK2 signaling

chemical name text :

(9 ,10 ,16 ,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

formula :

C 30 H 42 O 7

formula text :

C30H42O7

cas num :

7/3/22

2020 USD :

249

2021 USD :

259 USD

alt names :

Elatericin B, JSI 124

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage