Cucurbitacin I | Tocris Bioscience 1571/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cucurbitacin I

catalog :

1571/1

quantity :

1 mg

price :

325 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Martin Gallausiaux C, Larraufie P, Jarry A, Béguet Crespel F, Marinelli L, Ledue F, et al. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol. 2018;9:2838 pubmed publisher
Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, et al. Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene. 2016;35:5388-5399 pubmed publisher
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed publisher
Wan J, Zhao X, Vojtek A, Goldman D. Retinal injury, growth factors, and cytokines converge on Î²-catenin and pStat3 signaling to stimulate retina regeneration. Cell Rep. 2014;9:285-97 pubmed publisher
Koscsó B, Csóka B, Kókai E, Németh Z, Pacher P, Virag L, et al. Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol. 2013;94:1309-15 pubmed publisher
Stechishin O, Luchman H, Ruan Y, Blough M, Nguyen S, Kelly J, et al. On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Neuro Oncol. 2013;15:198-207 pubmed publisher
Dalvi P, Erbiceanu F, Irwin D, Belsham D. Direct regulation of the proglucagon gene by insulin, leptin, and cAMP in embryonic versus adult hypothalamic neurons. Mol Endocrinol. 2012;26:1339-55 pubmed publisher
Hamilton K, Simmons J, Ding S, Van Landeghem L, Lund P. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Mol Cancer Res. 2011;9:1718-31 pubmed publisher
Tiffon C, Adams J, van der Fits L, Wen S, Townsend P, Ganesan A, et al. The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells. Br J Pharmacol. 2011;162:1590-602 pubmed publisher
Bonifazi P, Zelante T, D Angelo C, De Luca A, Moretti S, Bozza S, et al. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol. 2009;2:362-74 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1571

SKU :

1571/1

product name :

Cucurbitacin I

description :

Selective inhibitor of STAT3/JAK2 signaling

target :

JAK Kinase Inhibitors

unit size :

1 mg

category :

Small Molecules

purity :

95%

storage :

Store at -20°C

observed molecular weight :

514.65

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

product keywords :

Selective inhibitors inhibits STAT3/JAK2 signaling signalling Janus Activated Kinase JAK Kinases Signal Transducers activators Transcription STAT CucurbitacinI ElatericinB JSI124 Elatericin B JSI 124 JAK STAT JAK Kinase 1571,

extended description :

Selective inhibitor of STAT3/JAK2 signaling

chemical name text :

(9 ,10 ,16 ,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

formula :

C30H42O7

formula text :

C30H42O7

cas num :

7/3/22

USD :

321

USD 2025 :

325 USD

product details :

Selective inhibitor of STAT3/JAK2 signaling

alt names :

Elatericin B,JSI 124

more info or order :

Tocris Bioscience product webpage