(S)-SNAP 5114 | Tocris Bioscience 1561 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(S)-SNAP 5114

catalog :

1561

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Patel B, Bright D, Mortensen M, FrÃ¸lund B, Smart T. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci. 2016;36:607-21 pubmed publisher
KÃ©kesi O, Ioja E, SzabÃ³ Z, Kardos J, HÃ©ja L. Recurrent seizure-like events are associated with coupled astroglial synchronization. Front Cell Neurosci. 2015;9:215 pubmed publisher
Herd M, Brown A, Lambert J, Belelli D. Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. J Neurosci. 2013;33:14850-68 pubmed publisher
KersantÃ© F, Rowley S, Pavlov I, GutiÃ¨rrez Mecinas M, Semyanov A, Reul J, et al. A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J Physiol. 2013;591:2429-41 pubmed publisher
Kinney G. GAT-3 transporters regulate inhibition in the neocortex. J Neurophysiol. 2005;94:4533-7 pubmed

product information

brand :

Tocris

master code :

1561

SKU :

1561/10

product name :

(S)-SNAP 5114

description :

GABA uptake inhibitor

target :

GABA Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

505.61

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 u M for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo .

catalog number base :

1561

product keywords :

GABA reuptake inhibitors inhibits BGT-1 GAT-2 GAT-3 Transporters Monoamine Neurotransmitter (S)-SNAP5114 GABA Transporters 1561,

extended description :

GABA uptake inhibitor

chemical name text :

1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid

formula :

C 30 H 35 NO 6

formula text :

C30H35NO6

cas num :

157604-55-2

2020 USD :

207

2021 USD :

216 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage