product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
CTAP
catalog :
1560/1
quantity :
1 mg
price :
226 USD
more info or order :
citations: 13
Reference
Nash B, Tarn K, Irollo E, Luchetta J, Festa L, Halcrow P, et al. Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons. Eneuro. 2019;6: pubmed publisher
Birdsong W, Jongbloets B, Engeln K, Wang D, Scherrer G, Mao T. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. elife. 2019;8: pubmed publisher
Fox P, Hentges S. Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity. J Neurosci. 2017;37:8667-8677 pubmed publisher
Gerhold K, Drdla Schutting R, Honsek S, Forsthuber L, Sandkühler J. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 2015;35:9580-94 pubmed publisher
Largent Milnes T, Brookshire S, Skinner D, Hanlon K, Giuvelis D, Yamamoto T, et al. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. J Pharmacol Exp Ther. 2013;347:7-19 pubmed publisher
Milan Lobo L, Enquist J, van Rijn R, Whistler J. Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS ONE. 2013;8:e58362 pubmed publisher
Pennock R, Dicken M, Hentges S. Multiple inhibitory G-protein-coupled receptors resist acute desensitization in the presynaptic but not postsynaptic compartments of neurons. J Neurosci. 2012;32:10192-200 pubmed publisher
Maguma H, Dewey W, Akbarali H. Differences in the characteristics of tolerance to ?-opioid receptor agonists in the colon from wild type and ?-arrestin2 knockout mice. Eur J Pharmacol. 2012;685:133-40 pubmed publisher
Krook Magnuson E, Luu L, Lee S, Varga C, Soltesz I. Ivy and neurogliaform interneurons are a major target of ?-opioid receptor modulation. J Neurosci. 2011;31:14861-70 pubmed publisher
Song C, Rahim R, Davey P, Bednar F, Bardi G, Zhang L, et al. Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5. J Biol Chem. 2011;286:20354-65 pubmed publisher
Sengupta R, Burbassi S, Shimizu S, Cappello S, Vallee R, Rubin J, et al. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. J Neurosci. 2009;29:2534-44 pubmed publisher
DiPatrizio N, Simansky K. Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. J Neurosci. 2008;28:9702-9 pubmed publisher
Happel C, Steele A, Finley M, Kutzler M, Rogers T. DAMGO-induced expression of chemokines and chemokine receptors: the role of TGF-beta1. J Leukoc Biol. 2008;83:956-63 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1560
SKU :
1560/1
product name :
CTAP
description :
Potent and selective u antagonist
target :
mu Opioid Receptor Antagonists
unit size :
1 mg
category :
Peptides
purity :
95%
storage :
Store at -20°C
observed molecular weight :
1104.32
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
CTAP is a potent and selective u opioid receptor antagonist (IC50 = 3.5 nM). Displays 1200-fold selectivity over opioid and somatostatin receptors. Brain penetrant and active in vivo .
product keywords :
Selective potent -opioid mu-opioid antagonists MOP Receptors OP3 Mu Opioid Receptors 1560,
extended description :
Potent and selective u antagonist
formula :
C51H69N13O11S2
formula text :
C51H69N13O11S2
cas num :
103429-32-9
USD :
216
USD 2025 :
226 USD
product details :
Potent and selective u antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK