AG 825 | Tocris Bioscience 1555 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AG 825

catalog :

1555

quantity :

10 mg (also 50 mg)

price :

151 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Wu L, Ramirez S, Andrews A, Leung W, Itoh K, Wu J, et al. Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem. 2016;136:250-7 pubmed publisher
Lee C, Lin Y, Bratman S, Feng W, Kuo A, Scheeren F, et al. Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation. Cancer Res. 2014;74:341-52 pubmed publisher
Akhtar S, Yousif M, Dhaunsi G, Sarkhouh F, Chandrasekhar B, Attur S, et al. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction. PLoS ONE. 2013;8:e67813 pubmed publisher
Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor ? in breast cancer. PLoS ONE. 2013;8:e55355 pubmed publisher
Kedrin D, Wyckoff J, Boimel P, Coniglio S, Hynes N, Arteaga C, et al. ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Clin Cancer Res. 2009;15:3733-9 pubmed publisher

product information

brand :

Tocris

master code :

1555

SKU :

1555/10

product name :

AG 825

description :

Selective ErbB2 inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

397.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective ErbB2 inhibitor (IC50 values are 0.15 and 19 M at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

catalog number base :

1555

product keywords :

Selective ErbB2 inhibitors inhibits Epidermal Growth Factors Receptors ErbB Her EGFR Receptor Tyrosine Kinases RTKs AG825 Tyrphostin AG 825 Tyrphostin AG 825 EGFR 1555,

extended description :

Selective ErbB2 inhibitor

chemical name text :

(E)-3-[3-[2-Benzothiazolythio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide

formula :

C 19 H 15 N 3 O 3 S 2

formula text :

C19H15N3O3S2

cas num :

149092-50-2

2020 USD :

145

2021 USD :

151 USD

alt names :

Tyrphostin AG 825

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage