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company name :
Tocris Bioscience
product type :
chemical
product name :
STO-609 acetate
catalog :
1551/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
148 USD
more info or order :
citations: 42
Reference
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York B, Li F, Lin F, Marcelo K, Mao J, Dean A, et al. Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Sci Rep. 2017;7:11793 pubmed publisher
Hashiguchi H, Sheng Z, Routh V, Gerzanich V, Simard J, Bryan J. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS ONE. 2017;12:e0184261 pubmed publisher
Kotla S, Singh N, Kirchhofer D, Rao G. Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking. J Biol Chem. 2017;292:14885-14901 pubmed publisher
Ha S, Jeong S, Yi K, Chung K, Hong C, Kim S, et al. Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells. J Biol Chem. 2017;292:13795-13808 pubmed publisher
Zhang P, Liu X, Li H, Chen Z, Yao X, Jin J, et al. TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway. Sci Rep. 2017;7:3158 pubmed publisher
Lv S, Xu Q, Sun E, Zhang J, Wu D. Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK. Sci Rep. 2016;6:23130 pubmed publisher
Horigane S, Ageta Ishihara N, Kamijo S, Fujii H, Okamura M, Kinoshita M, et al. Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization. Mol Brain. 2016;9:8 pubmed publisher
Obba S, Hizir Z, Boyer L, Selimoglu Buet D, Pfeifer A, Michel G, et al. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy. 2015;11:1114-29 pubmed publisher
Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
Lee K, Royston S, Vest M, Ley D, Lee S, Bolton E, et al. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity. Mol Brain. 2015;8:4 pubmed publisher
Zhu Y, Brown J, Sag D, Zhang L, Suttles J. Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages. J Immunol. 2015;194:584-94 pubmed publisher
Li H, Zhong X, Chau K, Santistevan N, Guo W, Kong G, et al. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nat Commun. 2014;5:5601 pubmed publisher
Figarola J, Singhal P, Rahbar S, Gugiu B, Awasthi S, Singhal S. COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. PLoS ONE. 2013;8:e83801 pubmed publisher
Mounier R, Theret M, Arnold L, Cuvellier S, Bultot L, Göransson O, et al. AMPK?1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab. 2013;18:251-64 pubmed publisher
Hutchins B, Klenke U, Wray S. Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Neurosci. 2013;33:11361-71 pubmed publisher
Kim H, Montana V, Jang H, Parpura V, Kim J. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem. 2013;288:22693-705 pubmed publisher
Iseli T, Turner N, Zeng X, Cooney G, Kraegen E, Yao S, et al. Activation of AMPK by bitter melon triterpenoids involves CaMKK?. PLoS ONE. 2013;8:e62309 pubmed publisher
Parker W, Orlova K, Parker W, Birnbaum J, Krymskaya V, Goncharov D, et al. Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder. Sci Transl Med. 2013;5:182ra53 pubmed publisher
Ma Y, Yang F, Wang Y, Du Z, Liu D, Guo H, et al. CaMKK? is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines. PLoS ONE. 2012;7:e47900 pubmed publisher
Ghislat G, Patron M, Rizzuto R, Knecht E. Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-? (CaMKK-?). J Biol Chem. 2012;287:38625-36 pubmed publisher
Zou L, Zhu Mauldin X, Marchase R, Paterson A, Liu J, Yang Q, et al. Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent. J Biol Chem. 2012;287:34419-31 pubmed publisher
El Gaamouch F, Buisson A, Moustié O, Lemieux M, Labrecque S, Bontempi B, et al. Interaction between ?CaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci. 2012;32:10767-79 pubmed publisher
Fortin D, Srivastava T, Dwarakanath D, Pierre P, Nygaard S, Derkach V, et al. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. J Neurosci. 2012;32:8127-37 pubmed publisher
Karacosta L, Foster B, Azabdaftari G, Feliciano D, Edelman A. A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression. J Biol Chem. 2012;287:24832-43 pubmed publisher
Kawashima J, Alquier T, Tsuji Y, Peroni O, Kahn B. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS ONE. 2012;7:e36335 pubmed publisher
Terry L, Vastag L, Rabinowitz J, Shenk T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2012;109:3071-6 pubmed publisher
Ashpole N, Song W, Brustovetsky T, Engleman E, Brustovetsky N, Cummins T, et al. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability. J Biol Chem. 2012;287:8495-506 pubmed publisher
Fu D, Wakabayashi Y, Lippincott Schwartz J, Arias I. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Proc Natl Acad Sci U S A. 2011;108:1403-8 pubmed publisher
Fogarty S, Hawley S, Green K, Saner N, Mustard K, Hardie D. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP. Biochem J. 2010;426:109-18 pubmed publisher
REECE K, Mazalouskas M, Wadzinski B. The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex. Biochem Biophys Res Commun. 2009;386:582-7 pubmed publisher
Soltoff S, Hedden L. Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells. Am J Physiol Cell Physiol. 2008;295:C590-9 pubmed publisher
Wayman G, Davare M, Ando H, Fortin D, Varlamova O, Cheng H, et al. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A. 2008;105:9093-8 pubmed publisher
Guire E, Oh M, Soderling T, Derkach V. Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I. J Neurosci. 2008;28:6000-9 pubmed publisher
Guest C, Deszo E, Hartman M, York J, Kelley K, Freund G. Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile. PLoS ONE. 2008;3:e1606 pubmed publisher
Göransson O, McBride A, Hawley S, Ross F, Shpiro N, Foretz M, et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem. 2007;282:32549-60 pubmed
Sanders M, Ali Z, Hegarty B, Heath R, Snowden M, Carling D. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem. 2007;282:32539-48 pubmed
Reihill J, Ewart M, Hardie D, Salt I. AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochem Biophys Res Commun. 2007;354:1084-8 pubmed
Høyer Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell. 2007;25:193-205 pubmed
Tamás P, Hawley S, Clarke R, Mustard K, Green K, Hardie D, et al. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J Exp Med. 2006;203:1665-70 pubmed
Hawley S, Pan D, Mustard K, Ross L, Bain J, Edelman A, et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005;2:9-19 pubmed
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1551
SKU :
1551/1
product name :
STO-609 acetate
description :
Selective CaM kinase kinase inhibitor
target :
Calcium Binding Protein Modulator Inhibitors
unit size :
1 mg (also 10 mg, 50 mg)
category :
Small Molecules
purity :
98%
storage :
Desiccate at RT
observed molecular weight :
374.35
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KK and CaM-KK respectively); competes for the ATP-binding site. Displays 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.
product keywords :
Selective CaM kinases inhibitors inhibits Ca2+ Binding Protein modulators Calcium Signaling Signalling Calmodulin-Activated Calcium Binding Protein CaM Kinase 1551,
extended description :
Selective CaM kinase kinase inhibitor
chemical name text :
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
formula :
C19H10N2O3.C2H4O2
formula text :
C19H10N2O3.C2H4O2
cas num :
1173022-21-3
USD :
146
USD 2025 :
148 USD
product details :
Selective CaM kinase kinase inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK