product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Cantharidin
catalog :
1548
quantity :
50 mg
price :
142 USD
more info or order :
citations: 5
Reference
Lang C, Campbell K, Ryan B, Carling P, Attar M, Vowles J, et al. Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell. 2019;24:93-106.e6 pubmed publisher
Shuhaibar L, Robinson J, Vigone G, Shuhaibar N, Egbert J, Baena V, et al. Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. elife. 2017;6: pubmed publisher
Polito M, Guiot E, Gangarossa G, Longueville S, Doulazmi M, Valjent E, et al. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Eneuro. 2015;2: pubmed publisher
Egbert J, Shuhaibar L, Edmund A, Van Helden D, Robinson J, Uliasz T, et al. Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes. Development. 2014;141:3594-604 pubmed publisher
Gray E, Guglietta R, Khakh B, O Dell T. Inhibitory interactions between phosphorylation sites in the C terminus of ?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. J Biol Chem. 2014;289:14600-11 pubmed publisher
product information
brand :
Tocris
master code :
1548
SKU :
1548/50
product name :
Cantharidin
description :
Protein phosphatase 1 and 2A inhibitor
target :
Protein Ser/Thr Phosphatase Inhibitors
category :
Small Molecules
unit size :
50 mg
observed molecular weight :
196.2
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 u M respectively); similar to okadaic acid (Cat. No. 1136). Displays 500-fold selectivity over PP2B.
catalog number base :
1548
product keywords :
Protein phosphatase 1 2A inhibitors inhibits Calcineurin Ser/Thr Phosphatases PP1 PP2A Protein Ser/Thr Phosphatases 1548,
extended description :
Protein phosphatase 1 and 2A inhibitor
chemical name text :
(3a ,4 ,7 ,7a )-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
formula :
C 10 H 12 O 4
formula text :
C10H12O4
cas num :
56-25-7
2020 USD :
142
2021 USD :
142 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK