(R)-(+)-Bay K 8644 | Tocris Bioscience 1545 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(R)-(+)-Bay K 8644

catalog :

1545

quantity :

10 mg (also 50 mg)

price :

282 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sidaway P, Teramoto N. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS ONE. 2014;9:e93803 pubmed publisher

product information

brand :

Tocris

master code :

1545

SKU :

1545/10

product name :

(R)-(+)-Bay K 8644

description :

CaV1.x blocker; (R)-(+)-enantiomer of ( )-Bay K 8644; also TMEM176B inhibitor

target :

Voltage-gated Calcium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

356.3

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate ( )-Bay K 8644 and (S)-(-)- enantiomer . Also TMEM176B inhibitor. Induces IL-1 secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers. . Racemate and ( S )-(-)-Enantiomer also available.

catalog number base :

1545

product keywords :

Ca2+-channel blockers L-type Calcium CaV Channels L-Type voltage-gated voltage-dependent Ca2+ (R)-(+)-BayK8644 stem cells TMEM176B transmembrane protein immune checkpoint inhibitors inhibits activates inflammasomes Cav1.x Channels Immune Checkpoints Inflammasomes 1545, Voltage-gated calcium channel blocker, voltage gated calcium channel, high-voltage activated Ca2+ channel, high voltage gated ca2+ channel

extended description :

CaV1.x blocker; (R)-(+)-enantiomer of ( )-Bay K 8644; also TMEM176B inhibitor

chemical name text :

(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

formula :

C 16 H 15 F 3 N 2 O 4

formula text :

C16H15F3N2O4

cas num :

98791-67-4

2020 USD :

276

2021 USD :

282 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage