chemical

(R)-(+)-Bay K 8644

1545/10

10 mg (also 50 mg)

354 USD

1545

1545/10

(R)-(+)-Bay K 8644

10 mg (also 50 mg)

CaV1.x blocker; (R)-(+)-enantiomer of ( )-Bay K 8644; also TMEM176B inhibitor

Cav1.x Channel Blockers

Small Molecules

98%

356.3

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5

( R )-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate ( )-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1 secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers. . Racemate and ( S )-(-)-Enantiomer also available.

CaV1.x blocker; (R)-(+)-enantiomer of ( )-Bay K 8644; also TMEM176B inhibitor

CaV1.x blocker; (R)-(+)-enantiomer of ( )-Bay K 8644; also TMEM176B inhibitor

(4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

C16H15F3N2O4

C16H15F3N2O4

98791-67-4

354 USD

CaV1.x blocker; (R)-(+)-enantiomer of ( )-Bay K 8644; also TMEM176B inhibitor

Store at +4°C