(+/-)-Bay K 8644 | Tocris Bioscience 1544/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(+/-)-Bay K 8644

catalog :

1544/10

quantity :

10 mg (also 50 mg)

price :

244 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Bellono N, Leitch D, Julius D. Molecular basis of ancestral vertebrate electroreception. Nature. 2017;543:391-396 pubmed publisher
Ets H, Seow C, Moreland R. Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon. Front Pharmacol. 2016;7:516 pubmed publisher
Sharma D, Tiwari B, Mehto S, Antony C, Kak G, Singh Y, et al. Suppression of Protective Responses upon Activation of L-Type Voltage Gated Calcium Channel in Macrophages during Mycobacterium bovis BCG Infection. PLoS ONE. 2016;11:e0163845 pubmed publisher
Cagalinec M, Liiv M, Hodurova Z, Hickey M, Vaarmann A, Mandel M, et al. Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. PLoS Biol. 2016;14:e1002511 pubmed publisher
Fransen P, Van Hove C, Leloup A, Martinet W, De Meyer G, Lemmens K, et al. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. PLoS ONE. 2015;10:e0121634 pubmed publisher
Mazzuca M, Mata K, Li W, Rangan S, Khalil R. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther. 2015;352:291-304 pubmed publisher
Grassin Delyle S, Abrial C, Fayad Kobeissi S, Brollo M, Faisy C, Alvarez J, et al. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res. 2013;14:134 pubmed publisher
Armstrong G, Drapeau P. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS. J Neurosci. 2013;33:1741-52 pubmed publisher
Lee C, Machold R, Witkovsky P, Rice M. TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons. J Neurosci. 2013;33:1157-68 pubmed publisher
Cerignoli F, Charlot D, Whittaker R, Ingermanson R, Gehalot P, Savchenko A, et al. High throughput measurement of Ca²? dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry. J Pharmacol Toxicol Methods. 2012;66:246-56 pubmed publisher
Yang C, Huang C, Hsu K. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. J Neurosci. 2012;32:7550-62 pubmed publisher
Saliba R, Kretschmannova K, Moss S. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. EMBO J. 2012;31:2937-51 pubmed publisher
Subramanian J, Morozov A. Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. J Neurosci. 2011;31:4755-64 pubmed publisher
Tian X, Kai L, Hockberger P, Wokosin D, Surmeier D. MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons. Mol Cell Neurosci. 2010;44:94-108 pubmed publisher

product information

brand :

Tocris

MasterCode :

1544

SKU :

1544/10

product name :

(+/-)-Bay K 8644

target :

Cav1.x Channel Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

356.3

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( )-Bay K 8644 is a L-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo . In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy. . ( S )-(-)-Enantiomer and ( R )-(+)-Enantiomer also available.

extended description :

CaV1.x activator

chemical name text :

1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

formula :

C 16 H 15 F 3 N 2 O 4

formula text :

C16H15F3N2O4

cas num :

71145-03-4

USD :

244 USD

product details :

CaV1.x activator

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage