DCPIB | Tocris Bioscience 1540 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DCPIB

catalog :

1540

quantity :

10 mg (also 50 mg)

price :

160 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
Lahey L, Mardjuki R, Wen X, Hess G, Ritchie C, Carozza J, et al. LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. Mol Cell. 2020;80:578-591.e5 pubmed publisher
Han Y, Kwon J, Won J, An H, Jang M, Woo J, et al. Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain. Exp Neurobiol. 2019;28:183-215 pubmed publisher
Woo J, Han Y, Koh W, Won J, Park M, An H, et al. Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol. 2019;28:30-42 pubmed publisher
Wong R, Chen W, Zhong X, Rutka J, Feng Z, Sun H. Swelling-induced chloride current in glioblastoma proliferation, migration, and invasion. J Cell Physiol. 2018;233:363-370 pubmed publisher
Ghosh A, Khandelwal N, Kumar A, Bera A. Leucine-rich repeat-containing 8B protein is associated with the endoplasmic reticulum Ca2+ leak in HEK293 cells. J Cell Sci. 2017;130:3818-3828 pubmed publisher
Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed publisher
CatalÃ¡n M, Kondo Y, PeÃ±a Munzenmayer G, Jaramillo Y, Liu F, Choi S, et al. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015;112:2263-8 pubmed publisher
Takada H, Furuya K, Sokabe M. Mechanosensitive ATP release from hemichannels and Ca²? influx through TRPC6 accelerate wound closure in keratinocytes. J Cell Sci. 2014;127:4159-71 pubmed publisher
Sabirov R, Kurbannazarova R, Melanova N, Okada Y. Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes. PLoS ONE. 2013;8:e55646 pubmed publisher
Hawkins E, Dewey W, Anitha M, Srinivasan S, Grider J, Akbarali H. Electrophysiological characteristics of enteric neurons isolated from the immortomouse. Dig Dis Sci. 2013;58:1516-27 pubmed publisher
Hyzinski García M, Vincent M, Haskew Layton R, Dohare P, Keller R, Mongin A. Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures. J Neurochem. 2011;118:140-52 pubmed publisher
Li A, Leung C, Peterson Yantorno K, Stamer W, Mitchell C, Civan M. Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. J Cell Physiol. 2012;227:172-82 pubmed publisher
Schlichter L, Mertens T, Liu B. Swelling activated Cl- channels in microglia: Biophysics, pharmacology and role in glutamate release. Channels (Austin). 2011;5:128-37 pubmed
Raucci F, Wijesinghe D, Chalfant C, Baumgarten C. Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes. Cardiovasc Res. 2010;86:55-62 pubmed publisher
Li G, Olson J. Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons. Am J Physiol Cell Physiol. 2008;295:C1550-60 pubmed publisher
Zhang Y, Zhang H, Feustel P, Kimelberg H. DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra. Exp Neurol. 2008;210:514-20 pubmed publisher

product information

brand :

Tocris

master code :

1540

SKU :

1540/10

product name :

DCPIB

description :

Blocker of VRAC/ICl, swell

target :

Other Chloride Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

427.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Volume-regulated anion channel (VRAC) blocker (IC50 ~ 2 u M in rat pancreatic -cells). Also blocks ICl,swell in various cardiovascular tissues (IC50 = 4.1 u M in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact -cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro . Also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels at 10 M, in vitro . Also inhibits VRAC-mediated 2 3 -cyclic-GMP-AMP (cGAMP) transport.

catalog number base :

1540

product keywords :

Selective blockers VSAC VRAC IClswell volume-sensitive anion channels chloride volume regulated LRRC8 cGAMP transporter transports inhibits inhibitor inhibitors K2P Other Chloride Channels Two-P Potassium Channels STING-Dependent Signaling 1540,

extended description :

Blocker of VRAC/ICl, swell

chemical name text :

4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid

formula :

C 22 H 28 Cl 2 O 4

formula text :

C22H28Cl2O4

cas num :

82749-70-0

2020 USD :

152

2021 USD :

160 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage