product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Icilin
catalog :
1531/10
quantity :
10 mg (also 50 mg)
price :
194 USD
more info or order :
citations: 6
Reference |
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Ganley R, Iwagaki N, Del Río P, Baseer N, Dickie A, Boyle K, et al. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets. J Neurosci. 2015;35:7626-42 pubmed publisher
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Proudfoot C, Garry E, Cottrell D, Rosie R, Anderson H, Robertson D, et al. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol. 2006;16:1591-605 pubmed
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Cat.No. 1531 - Icilin C16H13N3O4 CAS No. 36945-98-9
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1531
SKU :
1531/10
product name :
Icilin
description :
Activates cold receptors. Cooling agent
target :
TRPA1 Agonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at RT
observed molecular weight :
311.3
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 u M) more potently than menthol or low temperatures. Produces wet shakes in vivo .
product keywords :
activators novel cold receptor Cooling agent TRP Channels Transient Receptor Potential AG35 TRPA TRPM AG 3-5 TRPA1 TRPM 1531,
extended description :
Activates cold receptors. Cooling agent
chemical name text :
3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one
formula :
C16H13N3O4
formula text :
C16H13N3O4
cas num :
36945-98-9
USD :
188
USD 2025 :
194 USD
product details :
Activates cold receptors. Cooling agent
alt names :
AG 3-5
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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