Lovastatin | Tocris Bioscience 1530/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Lovastatin

catalog :

1530/10

quantity :

10 mg (also 50 mg)

price :

122 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher
Horlbeck M, Xu A, Wang M, Bennett N, Park C, Bogdanoff D, et al. Mapping the Genetic Landscape of Human Cells. Cell. 2018;174:953-967.e22 pubmed publisher
Leznicki P, Natarajan J, Bader G, Spevak W, Schlattl A, Abdul Rehman S, et al. Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J Cell Sci. 2018;131: pubmed publisher
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher
Ibrahim N, Mohamed N, Soelaiman I, Shuid A. The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model. Int J Environ Res Public Health. 2015;12:12958-76 pubmed publisher
Saqcena M, Patel D, Menon D, Mukhopadhyay S, Foster D. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Cell Cycle. 2015;14:2285-92 pubmed publisher
Nölting S, Giubellino A, Tayem Y, Young K, Lauseker M, Bullova P, et al. Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice. Endocrinology. 2014;155:2377-90 pubmed publisher
Rojo Arreola L, Long T, Asarnow D, Suzuki B, Singh R, Caffrey C. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS ONE. 2014;9:e87594 pubmed publisher
Buchovecky C, Turley S, Brown H, Kyle S, McDonald J, Liu B, et al. A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet. 2013;45:1013-20 pubmed publisher
Kah J, Wüstenberg A, Keller A, Sirma H, Montalbano R, Ocker M, et al. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncol Rep. 2012;28:1077-83 pubmed publisher
Vainio P, Lehtinen L, Mirtti T, Hilvo M, Seppanen Laakso T, Virtanen J, et al. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Oncotarget. 2011;2:1176-90 pubmed

product information

brand :

Tocris

MasterCode :

1530

SKU :

1530/10

product name :

Lovastatin

target :

HMG-CoA Reductase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

404.54

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Lovastatin is a potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Indirectly inhibits Rho-GTPase activity by depleting intracellular pool of isoprene residues. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro . Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

extended description :

Potent HMG-CoA reductase inhibitor

chemical name text :

(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate

formula :

C 24 H 36 O 5

formula text :

C24H36O5

cas num :

75330-75-5

USD :

122 USD

product details :

Potent HMG-CoA reductase inhibitor

alt names :

Mevinolin

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage