Mevastatin | Tocris Bioscience 1526 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mevastatin

catalog :

1526

quantity :

10 mg (also 50 mg)

price :

121 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Song Y, Subramanian K, Berberich M, Rodriguez S, Latorre I, Luria C, et al. A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Sci Data. 2019;6:190016 pubmed publisher
van der Kant R, Langness V, Herrera C, Williams D, Fong L, Leestemaker Y, et al. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019;24:363-375.e9 pubmed publisher
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher
Leznicki P, Natarajan J, Bader G, Spevak W, Schlattl A, Abdul Rehman S, et al. Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J Cell Sci. 2018;131: pubmed publisher
Vergnes L, Chin R, de Aguiar Vallim T, Fong L, Osborne T, Young S, et al. SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res. 2016;57:410-21 pubmed publisher
Brown D, Price L. Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Vet Microbiol. 2007;120:328-33 pubmed

product information

brand :

Tocris

master code :

1526

SKU :

1526/10

product name :

Mevastatin

description :

HMG-CoA reductase inhibitor

target :

HMG-CoA Reductase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

390.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo . Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

catalog number base :

1526

product keywords :

HMG-CoA reductases inhibitors inhibits statins Compactin HMG-CoA Reductase 1526,

extended description :

HMG-CoA reductase inhibitor

chemical name text :

(2S)-2-Methyl-(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl butanoate

formula :

C 23 H 34 O 5

formula text :

C23H34O5

cas num :

73573-88-3

2020 USD :

118

2021 USD :

121 USD

alt names :

Compactin

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage