5-Iodo-A-85380 dihydrochloride | Tocris Bioscience 1518 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5-Iodo-A-85380 dihydrochloride

catalog :

1518

quantity :

10 mg

price :

317 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Chatzidaki A, Fouillet A, Li J, Dage J, Millar N, Sher E, et al. Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons. PLoS ONE. 2015;10:e0125116 pubmed publisher
Brown J, Wonnacott S. Sazetidine-A Activates and Desensitizes Native ?7 Nicotinic Acetylcholine Receptors. Neurochem Res. 2015;40:2047-54 pubmed publisher
Hamouda A, Jin X, Sanghvi M, Srivastava S, Pandhare A, Duddempudi P, et al. Photoaffinity labeling the agonist binding domain of alpha4beta4 and alpha4beta2 neuronal nicotinic acetylcholine receptors with [(125)I]epibatidine and 5[(125)I]A-85380. Biochim Biophys Acta. 2009;1788:1987-95 pubmed publisher

product information

brand :

Tocris

master code :

1518

SKU :

1518/10

product name :

5-Iodo-A-85380 dihydrochloride

description :

High affinity 4 2 and 6 2 subtype-selective nAChR agonist

target :

Nicotinic (a4b2) Receptor Agonists

category :

Small Molecules

unit size :

10 mg

purity :

99%

observed molecular weight :

363.03

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A highly potent and subtype-selective agonist for the 4 2 and 6 2 nicotinic acetylcholine receptors. Activates -CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to 6 2 and 4 2 (EC50 values are 12.7 and ~35 nM respectively). ~5000-, 25000- and 140000-fold selective over 3 4, 7 and muscle nAChR receptors respectively. . Precursor also available.

catalog number base :

1518

product keywords :

High affinity 4 2 a4b2 6 2 alpha6beta2 a6b2 subtype-selective agonists nicotinic Receptors Acetylcholine nAChR Non-Selective Subtypes Other 5IA85380 Nicotinic Receptors (Other Subtypes) Nicotinic (a4b2) Receptors 1518,

extended description :

High affinity 4 2 and 6 2 subtype-selective nAChR agonist

chemical name text :

3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride

formula :

C 9 H 11 IN 2 O.2HCl

formula text :

C9H11IN2O.2HCl

cas num :

1217837-17-6

2020 USD :

304

2021 USD :

317 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage