17-AAG | Tocris Bioscience 1515/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

17-AAG

catalog :

1515/1

quantity :

1 mg

price :

229 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Siebert C, Ciato D, Murakami M, Frei Stuber L, Perez Rivas L, Monteserin Garcia J, et al. Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma. Front Endocrinol (Lausanne). 2019;10:487 pubmed publisher
Sontake V, Wang Y, Kasam R, Sinner D, Reddy G, Naren A, et al. Hsp90 regulation of fibroblast activation in pulmonary fibrosis. JCI Insight. 2017;2:e91454 pubmed publisher
Truman A, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum S, et al. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics. 2015;112:285-300 pubmed publisher
Fang Q, Inanç B, Schamus S, Wang X, Wei L, Brown A, et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase Î². Nat Commun. 2014;5:5513 pubmed publisher
Donnelly N, Passerini V, DÃ¼rrbaum M, Stingele S, StorchovÃ¡ Z. HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells. EMBO J. 2014;33:2374-87 pubmed publisher
Hughes J, Rødland M, Hasmann M, Madshus I, Stang E. Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab. Pharmaceuticals (Basel). 2012;5:674-89 pubmed publisher

product information

brand :

Tocris

MasterCode :

1515

SKU :

1515/1

product name :

17-AAG

target :

HSP90 Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

585.7

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

17-AAG is an inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo . Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro .

extended description :

Selective Hsp90 inhibitor

chemical name text :

17-Demethoxy-17-(2-propenylamino)geldanamycin

formula :

C 31 H 43 N 3 O 8

formula text :

C31H43N3O8

cas num :

75747-14-7

USD :

229 USD

product details :

Selective Hsp90 inhibitor

alt names :

NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage