product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SR 59230A hydrochloride
catalog :
1511
quantity :
10 mg (also 50 mg)
price :
220 USD
more info or order :
citations: 14
Reference
González García I, CONTRERAS C, Estévez Salguero Á, Ruiz Pino F, Colsh B, Pensado I, et al. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell Rep. 2018;25:413-423.e5 pubmed publisher
Martínez Sánchez N, Seoane Collazo P, CONTRERAS C, Varela L, Villarroya J, Rial Pensado E, et al. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab. 2017;26:212-229.e12 pubmed publisher
Lavine J, Farnoodian M, Wang S, Darjatmoko S, Wright L, Gamm D, et al. ?2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 2017;58:299-308 pubmed publisher
Sun F, Ding X, An S, Tang Y, Yang X, Teng L, et al. Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling. Sci Rep. 2015;5:15950 pubmed publisher
Armaiz Pena G, Gonzalez Villasana V, Nagaraja A, Rodriguez Aguayo C, Sadaoui N, Stone R, et al. Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget. 2015;6:4266-73 pubmed
Ataka K, Asakawa A, Nagaishi K, Kaimoto K, Sawada A, Hayakawa Y, et al. Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice. PLoS ONE. 2013;8:e81744 pubmed publisher
Brosnahan A, Vulchanova L, Witta S, Dai Y, Jones B, Brown D. Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells. J Neuroimmunol. 2013;259:8-16 pubmed publisher
Lavine J, Sang Y, Wang S, Ip M, Sheibani N. Attenuation of choroidal neovascularization by ?(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 2013;131:376-82 pubmed publisher
Rankovic V, Landgraf P, Kanyshkova T, Ehling P, Meuth S, Kreutz M, et al. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via ?-adrenergic signaling in thalamocortical relay neurons. PLoS ONE. 2011;6:e27474 pubmed publisher
Enriori P, Sinnayah P, Simonds S, Garcia Rudaz C, Cowley M. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci. 2011;31:12189-97 pubmed publisher
Sood A, Armaiz Pena G, Halder J, Nick A, Stone R, Hu W, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest. 2010;120:1515-23 pubmed publisher
Maupoil V, Bronquard C, Freslon J, Cosnay P, Findlay I. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol. 2007;150:899-905 pubmed
Nackley A, Tan K, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 2007;128:199-208 pubmed
Cirino G, Sorrentino R, di Villa Bianca R, Popolo A, Palmieri A, Imbimbo C, et al. Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Proc Natl Acad Sci U S A. 2003;100:5531-6 pubmed
product information
brand :
Tocris
master code :
1511
SKU :
1511/10
product name :
SR 59230A hydrochloride
description :
Potent and selective 3 antagonist
target :
Adrenergic beta-3 Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
361.91
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective 3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for 3, 1 and 2 receptors respectively). Orally active in vivo . Also available as part of the -Adrenoceptor Antagonist Tocriset .
catalog number base :
1511
product keywords :
Potent selective 3-adrenoceptor b3-adrenoceptor 3-adrenergic b3-adrenergic antagonists Receptors SR59230A hydrochloride Adrenergic Beta-3 Receptors 1511,
extended description :
Potent and selective 3 antagonist
chemical name text :
1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride
formula :
C 21 H 27 NO 2 .HCl
formula text :
C21H27NO2.HCl
cas num :
1135278-41-9
2020 USD :
209
2021 USD :
220 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK