GW 9662 | Tocris Bioscience 1508/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 9662

catalog :

1508/10

quantity :

10 mg (also 50 mg)

price :

202 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Smith D, Martinelli R, Besra G, Illarionov P, Szatmari I, Brazda P, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl). 2019;: pubmed publisher
Guo B, Huang X, Lee M, Lee S, Broxmeyer H. Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat Med. 2018;24:360-367 pubmed publisher
Helmy M, Helmy M, El Mas M. Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs. PLoS ONE. 2015;10:e0142303 pubmed publisher
Kotla S, Rao G. Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-Î³ in CD36 Protein Expression and Foam Cell Formation. J Biol Chem. 2015;290:30306-20 pubmed publisher
Chen T, Shih C, Hsu W, Chou T. Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets. PLoS ONE. 2015;10:e0127054 pubmed publisher
Shih C, Lin I, Ding J, Chen F, Chou T. Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity. Br J Pharmacol. 2014;171:1490-1500 pubmed publisher
Ramachandran L, Manu K, Shanmugam M, Li F, Siveen K, Vali S, et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer. J Biol Chem. 2012;287:38028-40 pubmed publisher
Mottillo E, Bloch A, Leff T, Granneman J. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Biol Chem. 2012;287:25038-48 pubmed publisher
Scuderi C, Valenza M, Stecca C, Esposito G, Carratu M, Steardo L. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-?. J Neuroinflammation. 2012;9:49 pubmed publisher
Esposito G, Scuderi C, Valenza M, Togna G, Latina V, De Filippis D, et al. Cannabidiol reduces A?-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR? involvement. PLoS ONE. 2011;6:e28668 pubmed publisher
Ali F, Armstrong P, Dhanji A, Tucker A, Paul Clark M, Mitchell J, et al. Antiplatelet actions of statins and fibrates are mediated by PPARs. Arterioscler Thromb Vasc Biol. 2009;29:706-11 pubmed publisher
Postea O, Koenen R, Hristov M, Weber C, Ludwig A. Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo. J Cell Mol Med. 2008;12:1700-9 pubmed publisher
Ali F, Davidson S, Moraes L, Traves S, Paul Clark M, Bishop Bailey D, et al. Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta. FASEB J. 2006;20:326-8 pubmed

product information

brand :

Tocris

MasterCode :

1508

SKU :

1508/10

product name :

GW 9662

target :

PPAR gamma Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

276.68

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GW 9662 is a selective irreversible PPAR antagonist (IC50 values are 3.3, 32 and 2000 nM for PPAR , PPAR and PPAR respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 u M), therefore is more potent than BADGE. Anticancer, inhibits growth of human mammary tumor cell lines.

extended description :

Selective covalent PPAR antagonist

chemical name text :

2-Chloro-5-nitro-N-phenylbenzamide

formula :

C 13 H 9 N 2 O 3 Cl

formula text :

C13H9N2O3Cl

cas num :

22978-25-2

USD :

202 USD

product details :

Selective covalent PPAR antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage