product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
FR 122047 hydrochloride
catalog :
1507
quantity :
10 mg (also 50 mg)
price :
193 USD
more info or order :
citations: 6
Reference
Tunaru S, Chennupati R, Nusing R, Offermanns S. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS ONE. 2016;11:e0163633 pubmed publisher
Lu L, Sun H, Zhang W, Chai Z, Zhu X, Kong L, et al. Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma. PLoS ONE. 2013;8:e65023 pubmed publisher
Tunaru S, Althoff T, Nusing R, Diener M, Offermanns S. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012;109:9179-84 pubmed publisher
Passafaro D, Sterin Borda L, Reina S, Borda E. Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Dent Res J (Isfahan). 2011;8:138-45 pubmed
Chia E, Kagota S, Wijekoon E, McGuire J. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 2011;11:10 pubmed publisher
Ray N, Bisher M, Enquist L. Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. J Virol. 2004;78:12964-74 pubmed
product information
brand :
Tocris
master code :
1507
SKU :
1507/10
product name :
FR 122047 hydrochloride
description :
Cyclooxygenase (COX-1) inhibitor
target :
Cyclooxygenase Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
459.99
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.028 and 65 u M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .
catalog number base :
1507
product keywords :
Cyclooxygenase COX-1 inhibitors inhibits Oxygenases Oxidases FR122047 hydrochloride Cyclooxygenase 1507,
extended description :
Cyclooxygenase (COX-1) inhibitor
chemical name text :
1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride
formula :
C 23 H 25 N 3 O 3 S.HCl
formula text :
C23H25N3O3S.HCl
cas num :
130717-51-0
2020 USD :
193
2021 USD :
193 USD
storage :
Desiccate at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK