product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
BQ 788 sodium salt
catalog :
1500/1
quantity :
1 mg
price :
437 USD
more info or order :
citations: 8
Reference
Durgan D, Crossland R, Lloyd E, Phillips S, Bryan R. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B. J Cereb Blood Flow Metab. 2015;35:402-11 pubmed publisher
Patel C, Narayanan S, Zhang W, Xu Z, Sukumari Ramesh S, Dhandapani K, et al. Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy. Am J Pathol. 2014;184:3040-51 pubmed publisher
Sanchez A, Martinez P, Munoz M, Benedito S, Garcia Sacristan A, Hernandez M, et al. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol. 2014;171:5682-95 pubmed publisher
Ou M, Dang Y, Mazzuca M, Basile R, Khalil R. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol. 2014;229:489-501 pubmed publisher
Allahdadi K, Hannan J, Tostes R, Webb R. Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation. J Sex Med. 2010;7:2096-2103 pubmed publisher
Yeligar S, Tsukamoto H, Kalra V. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol. 2009;183:5232-43 pubmed publisher
Sutcliffe A, Clarke D, Bradbury D, Corbett L, Patel J, Knox A. Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1. Br J Pharmacol. 2009;157:436-50 pubmed publisher
McQueen D, Noble M, Bond S. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol. 2007;151:278-84 pubmed
product information
brand :
Tocris
MasterCode :
1500
SKU :
1500/1
product name :
BQ 788 sodium salt
target :
Endothelin ETB Receptor Antagonists
category :
Small Molecules
unit size :
1 mg
purity :
95%
observed molecular weight :
663.79
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BQ 788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).
extended description :
Selective ETB antagonist
chemical name text :
N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
formula :
C 34 H 50 N 5 NaO 7
formula text :
C34H50N5NaO7
cas num :
156161-89-6
USD :
437 USD
product details :
Selective ETB antagonist
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK