CL 316243 disodium salt | Tocris Bioscience 1499 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CL 316243 disodium salt

catalog :

1499

quantity :

10 mg (also 50 mg)

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
Blaszkiewicz M, Willows J, Dubois A, Waible S, DiBello K, Lyons L, et al. Neuropathy and neural plasticity in the subcutaneous white adipose depot. PLoS ONE. 2019;14:e0221766 pubmed publisher
Feng Z, Wei Y, Zhang Y, Qiu Y, Liu X, Su L, et al. Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression. Theranostics. 2019;9:3501-3514 pubmed publisher
De Lima Junior J, Souza G, Moura Assis A, Gaspar R, Gaspar J, Rocha A, et al. Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency. EBioMedicine. 2019;39:436-447 pubmed publisher
Chen Q, Huang L, Pan D, Zhu L, Wang Y. Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis. Cell Rep. 2018;22:2860-2872 pubmed publisher
Masand R, Paulo E, Wu D, Wang Y, Swaney D, Jimenez Morales D, et al. Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab. 2018;27:616-629.e4 pubmed publisher
Saxton S, Ryding K, Aldous R, Withers S, Ohanian J, Heagerty A. Role of Sympathetic Nerves and Adipocyte Catecholamine Uptake in the Vasorelaxant Function of Perivascular Adipose Tissue. Arterioscler Thromb Vasc Biol. 2018;38:880-891 pubmed publisher
Gonzalez Hurtado E, Lee J, Choi J, Wolfgang M. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab. 2018;7:45-56 pubmed publisher
Fischer C, Seki T, Lim S, Nakamura M, Andersson P, Yang Y, et al. A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning. Nat Commun. 2017;8:2079 pubmed publisher
Huang L, Pan D, Chen Q, Zhu L, Ou J, Wabitsch M, et al. Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun. 2017;8:68 pubmed publisher
Li Y, Li X, Jiang T, Fan J, Zheng X, Shi X, et al. An Additive Effect of Promoting Thermogenic Gene Expression in Mice Adipose-Derived Stromal Vascular Cells by Combination of Rosiglitazone and CL316,243. Int J Mol Sci. 2017;18: pubmed publisher
Chen Y, Buyel J, Hanssen M, Siegel F, Pan R, Naumann J, et al. Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity. Nat Commun. 2016;7:11420 pubmed publisher
Kashyap M, Yoshimura N, Smith P, Chancellor M, Tyagi P. Characterization of the role of HCN channels in Î²3-adrenoceptor mediated rat bladder relaxation. Bladder (San Franc). 2015;2: pubmed
Patsouris D, Qi P, Abdullahi A, Stanojcic M, Chen P, Parousis A, et al. Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans. Cell Rep. 2015;13:1538-44 pubmed publisher
Nagai H, Kuwahira I, Schwenke D, Tsuchimochi H, Nara A, Ogura S, et al. Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via Î²3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia. PLoS ONE. 2015;10:e0131923 pubmed publisher
BerbÃ©e J, Boon M, Khedoe P, Bartelt A, Schlein C, Worthmann A, et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015;6:6356 pubmed publisher
MÃ¶ssenbÃ¶ck K, Vegiopoulos A, Rose A, Sijmonsma T, Herzig S, Schafmeier T. Browning of white adipose tissue uncouples glucose uptake from insulin signaling. PLoS ONE. 2014;9:e110428 pubmed publisher
Pan D, Mao C, Quattrochi B, Friedline R, Zhu L, Jung D, et al. MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun. 2014;5:4725 pubmed publisher
Suarez J, Rivera P, Arrabal S, Crespillo A, Serrano A, Baixeras E, et al. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech. 2014;7:129-41 pubmed publisher
Rieg A, Rossaint R, Uhlig S, Martin C. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices. PLoS ONE. 2011;6:e29698 pubmed publisher
Enriori P, Sinnayah P, Simonds S, Garcia Rudaz C, Cowley M. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci. 2011;31:12189-97 pubmed publisher
Nackley A, Tan K, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 2007;128:199-208 pubmed

product information

brand :

Tocris

master code :

1499

SKU :

1499/10

product name :

CL 316243 disodium salt

description :

Highly selective 3 agonist

target :

Adrenergic beta-3 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

465.8

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and highly selective 3-adrenoceptor agonist (EC50 = 3 nM); 10000-fold selective over 1 and 2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo .

catalog number base :

1499

product keywords :

selective 3-adrenoceptor b3-adrenoceptor 3-adrenergic b3-adrenergic agonists Receptors CL316243 disodium salt 151126-84-0 Adrenergic Beta-3 Receptors 1499,

extended description :

Highly selective 3 agonist

chemical name text :

5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt

formula :

C 20 H 18 ClNNa 2 O 7

formula text :

C20H18ClNNa2O7

cas num :

138908-40-4

2020 USD :

203

2021 USD :

214 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage