product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SP 600125
catalog :
1496/10
quantity :
10 mg (also 50 mg)
price :
124 USD
more info or order :
citations: 108
Reference
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product information
brand :
Tocris
MasterCode :
1496
SKU :
1496/10
product name :
SP 600125
target :
JNK/c-jun Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
220.23
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SP 600125 is a selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38 and a range of enzymes. Active in vivo . Exhibits reduced selectivity over other protein kinases under certain conditions. SP 600125 protects renal tubular epithelial cells from ischemia/reperfusion-induced apoptosis. Promotes chondrogenesis of bone mesenchymal stem cells by inhibition of TNF- -induced inflammation. Adipogenesis from MSCs is also promoted by SP 600125. Essential component of medium for maintaining stem cells in naive pluripotent state.
extended description :
Selective JNK inhibitor
chemical name text :
Anthra[1-9-cd]pyrazol-6(2H)-one
formula :
C 14 H 8 N 2 O
formula text :
C14H8N2O
cas num :
129-56-6
USD :
124 USD
product details :
Selective JNK inhibitor
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK