product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
DPN
catalog :
1494/10
quantity :
10 mg (also 50 mg)
price :
190 USD
more info or order :
citations: 107
Reference
Zhou X, Li M, Xiao M, Ruan Q, Chu Z, Ye Z, et al. ERβ Accelerates Diabetic Wound Healing by Ameliorating Hyperglycemia-Induced Persistent Oxidative Stress. Front Endocrinol (Lausanne). 2019;10:499 pubmed publisher
Loiola R, Wickstead E, Solito E, McArthur S. Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1. Front Endocrinol (Lausanne). 2019;10:420 pubmed publisher
Munive V, Zegarra Valdivia J, Herrero Labrador R, Fernandez A, Aleman I. Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice. Aging (Albany NY). 2019;11:174-184 pubmed publisher
Yakimchuk K, Bangalore Revanna C, Huang D, Inzunza J, Okret S. Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein. Endocr Connect. 2018;: pubmed publisher
Barreto Andrade J, de Fátima L, Campello R, Guedes J, De Freitas H, Machado M. Estrogen Receptor 1 (ESR1) Enhances Slc2a4/GLUT4 Expression by a SP1 Cooperative Mechanism. Int J Med Sci. 2018;15:1320-1328 pubmed publisher
Benhadjeba S, Edjekouane L, Sauvé K, Carmona E, Tremblay A. Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer. Mol Oncol. 2018;12:1689-1705 pubmed publisher
Fátima L, Campello R, Santos R, Freitas H, Frank A, Machado U, et al. Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue. Sci Rep. 2017;7:16716 pubmed publisher
Lu S, Sun C, Miao C, Zhao Z. ER? compensates for the absence of ER? function to promote osteoblast viability by inhibition of SOST signaling. Exp Ther Med. 2017;14:3387-3392 pubmed publisher
Shults C, Dingwall C, Kim C, Pinceti E, Rao Y, Pak T. 17β-estradiol regulates the RNA-binding protein Nova1, which then regulates the alternative splicing of estrogen receptor β in the aging female rat brain. Neurobiol Aging. 2018;61:13-22 pubmed publisher
Villar Pazos S, Martinez Pinna J, Castellano Muñoz M, Alonso Magdalena P, Marroquí L, Quesada I, et al. Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on ca2+ entry in mouse pancreatic β-cells. Sci Rep. 2017;7:11770 pubmed publisher
Lu J, Jin P, Gao W, Wang D, Sheng J. Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β. Oncotarget. 2017;8:38767-38779 pubmed publisher
Caballero I, Boyd J, Almiñana C, Sánchez López J, Basatvat S, Montazeri M, et al. Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol. Sci Rep. 2017;7:40981 pubmed publisher
Stacey W, Bhave S, Uht R. Mechanisms by Which 17β-Estradiol (E2) Suppress Neuronal cox-2 Gene Expression. PLoS ONE. 2016;11:e0161430 pubmed publisher
Pastore M, Talwar S, Conley M, Magness R. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells. Biol Reprod. 2016;94:139 pubmed publisher
Ma Y, Guo H, Zhang L, Tao L, Yin A, Liu Z, et al. Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β. Sci Rep. 2016;6:21467 pubmed publisher
Ma H, Gollahon L. ER? Mediates Estrogen-Induced Expression of the Breast Cancer Metastasis Suppressor Gene BRMS1. Int J Mol Sci. 2016;17: pubmed publisher
Castro J, Araya G, Inostroza P, Hidalgo P, González Ramos R, Sovino H, et al. Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation. Biol Res. 2015;48:56 pubmed publisher
Suwanna N, Thangnipon W, Kumar S, de Vellis J. Neuroprotection by diarylpropionitrile in mice with spinal cord injury. EXCLI J. 2014;13:1097-103 pubmed
Peržeľová V, Sabol F, Vasilenko T, Novotny M, Kovác I, Slezák M, et al. Pharmacological activation of estrogen receptors-? and -? differentially modulates keratinocyte differentiation with functional impact on wound healing. Int J Mol Med. 2016;37:21-8 pubmed publisher
Hamilton N, Márquez Garbán D, Mah V, Fernando G, Elshimali Y, Garbán H, et al. Biologic roles of estrogen receptor-β and insulin-like growth factor-2 in triple-negative breast cancer. Biomed Res Int. 2015;2015:925703 pubmed publisher
Mittelman Smith M, Wong A, Kathiresan A, Micevych P. Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons. Endocrinology. 2015;156:2162-73 pubmed publisher
Gao X, Ma J, Chen Y, Wang H. Rapid responses and mechanism of action for low-dose bisphenol S on ex vivo rat hearts and isolated myocytes: evidence of female-specific proarrhythmic effects. Environ Health Perspect. 2015;123:571-8 pubmed publisher
Zhou Y, Shen J, Xia L, Wang Y. Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling. Cancer Cell Int. 2014;14:540 pubmed publisher
Harvey C, Chen J, Bagnell C, Uzumcu M. Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro. Reprod Toxicol. 2015;51:72-8 pubmed publisher
Mazzuca M, Mata K, Li W, Rangan S, Khalil R. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther. 2015;352:291-304 pubmed publisher
Greaves E, Grieve K, Horne A, Saunders P. Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis. J Clin Endocrinol Metab. 2014;99:E1738-43 pubmed publisher
Ciucci A, Meco D, De Stefano I, Travaglia D, Zannoni G, Scambia G, et al. Gender effect in experimental models of human medulloblastoma: does the estrogen receptor ? signaling play a role?. PLoS ONE. 2014;9:e101623 pubmed publisher
Colciago A, Ruscica M, Mornati O, Piccolella M, Montagnani Marelli M, Eberini I, et al. In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells. Biomed Res Int. 2014;2014:801473 pubmed publisher
Ogo Y, Taniuchi S, Ojima F, Hayashi S, Murakami I, Saito Y, et al. IGF-1 gene expression is differentially regulated by estrogen receptors α and β in mouse endometrial stromal cells and ovarian granulosa cells. J Reprod Dev. 2014;60:216-23 pubmed
Goodman W, Garg R, Reuter B, Mattioli B, Rissman E, Pizarro T. Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn's-like ileitis. Mucosal Immunol. 2014;7:1255-65 pubmed publisher
Nag S, Mokha S. Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates ?2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat. Neuroscience. 2014;267:122-34 pubmed publisher
Murata T, Narita K, Ichimaru T. Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. J Reprod Dev. 2014;60:55-61 pubmed
Dong W, Zhang H, Li J, Guan H, He L, Wang Z, et al. Estrogen Induces Metastatic Potential of Papillary Thyroid Cancer Cells through Estrogen Receptor ? and ?. Int J Endocrinol. 2013;2013:941568 pubmed publisher
Jonsson P, Katchy A, Williams C. Support of a bi-faceted role of estrogen receptor ? (ER?) in ER?-positive breast cancer cells. Endocr Relat Cancer. 2014;21:143-60 pubmed publisher
Khalaj A, Yoon J, Nakai J, Winchester Z, Moore S, Yoo T, et al. Estrogen receptor (ER) ? expression in oligodendrocytes is required for attenuation of clinical disease by an ER? ligand. Proc Natl Acad Sci U S A. 2013;110:19125-30 pubmed publisher
Watanabe K, Nemoto T, Akira S, Takeshita T, Shibasaki T. Estrogens downregulate urocortin 2 expression in rat uterus. J Endocrinol. 2013;219:269-78 pubmed publisher
Wardell J, Hodgkinson K, Binder A, Seymour K, Korach K, Vanderhyden B, et al. Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors. Biol Reprod. 2013;89:116 pubmed publisher
Boulware M, Heisler J, Frick K. The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling. J Neurosci. 2013;33:15184-94 pubmed publisher
Spence R, Wisdom A, Cao Y, Hill H, Mongerson C, Stapornkul B, et al. Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ER? signaling on astrocytes but not through ER? signaling on astrocytes or neurons. J Neurosci. 2013;33:10924-33 pubmed publisher
Greaves E, Collins F, Critchley H, Saunders P. ER?-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1. Hum Reprod. 2013;28:2490-501 pubmed publisher
Takeda S, Yoshida K, Nishimura H, Harada M, Okajima S, Miyoshi H, et al. ?(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor ? (ER?). Chem Res Toxicol. 2013;26:1073-9 pubmed publisher
Zhang H, Liu Y, Wang L, Li Z, Zhang H, Wu J, et al. Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat. J Lipid Res. 2013;54:345-57 pubmed publisher
Privette Vinnedge L, Ho S, Wikenheiser Brokamp K, Wells S. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS ONE. 2012;7:e46985 pubmed publisher
Yang W, Lu Y, Xu Y, Xu L, Zheng W, Wu Y, et al. Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs). J Biol Chem. 2012;287:40140-9 pubmed publisher
Simpkins F, Hevia Paez P, Sun J, Ullmer W, Gilbert C, Da Silva T, et al. Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo. Clin Cancer Res. 2012;18:5911-23 pubmed publisher
Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
Richardson T, Yu A, Wen Y, Yang S, Simpkins J. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts. PLoS ONE. 2012;7:e34600 pubmed publisher
Tammimies K, Tapia Paez I, Rüegg J, Rosin G, Kere J, Gustafsson J, et al. The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor ? and DNA methylation. Mol Endocrinol. 2012;26:619-29 pubmed publisher
Patisaul H, Losa Ward S, Todd K, McCaffrey K, Mickens J. Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis. Biol Sex Differ. 2012;3:2 pubmed publisher
Wang Y, Kuehl Kovarik M. Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons. Brain Res. 2012;1436:81-91 pubmed publisher
Kastenberger I, Lutsch C, Schwarzer C. Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol. Psychopharmacology (Berl). 2012;221:527-35 pubmed publisher
González Arenas A, Hansberg Pastor V, Hernández Hernández O, González García T, Henderson Villalpando J, Lemus Hernández D, et al. Estradiol increases cell growth in human astrocytoma cell lines through ER? activation and its interaction with SRC-1 and SRC-3 coactivators. Biochim Biophys Acta. 2012;1823:379-86 pubmed publisher
Tashiro A, Okamoto K, Bereiter D. Rapid estrogenic effects on TMJ-responsive brainstem neurons. J Dent Res. 2012;91:210-4 pubmed publisher
Shanle E, Hawse J, Xu W. Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands. Biochem Pharmacol. 2011;82:1940-9 pubmed publisher
Tomicek N, Miller Lee J, Hunter J, Korzick D. Estrogen receptor beta does not influence ischemic tolerance in the aged female rat heart. Cardiovasc Ther. 2013;31:32-7 pubmed publisher
Filice E, Angelone T, De Francesco E, Pellegrino D, Maggiolini M, Cerra M. Crucial role of phospholamban phosphorylation and S-nitrosylation in the negative lusitropism induced by 17?-estradiol in the male rat heart. Cell Physiol Biochem. 2011;28:41-52 pubmed publisher
Zheng S, Huang J, Zhou K, Zhang C, Xiang Q, Tan Z, et al. 17?-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin. PLoS ONE. 2011;6:e22439 pubmed publisher
Sebag I, Gillis M, Calderone A, Kasneci A, Meilleur M, Haddad R, et al. Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice. Am J Physiol Heart Circ Physiol. 2011;301:H1706-15 pubmed publisher
Baquie M, St Onge L, Kerr Conte J, Cobo Vuilleumier N, Lorenzo P, Jimenez Moreno C, et al. The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis. Hum Mol Genet. 2011;20:2823-33 pubmed publisher
Seredynski A, Ball G, Balthazart J, Charlier T. Specific activation of estrogen receptor alpha and beta enhances male sexual behavior and neuroplasticity in male Japanese quail. PLoS ONE. 2011;6:e18627 pubmed publisher
Giannoni E, Guignard L, Knaup Reymond M, Perreau M, Roth Kleiner M, Calandra T, et al. Estradiol and progesterone strongly inhibit the innate immune response of mononuclear cells in newborns. Infect Immun. 2011;79:2690-8 pubmed publisher
Lindberg K, Helguero L, Omoto Y, Gustafsson J, Haldosén L. Estrogen receptor ? represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity. Breast Cancer Res. 2011;13:R43 pubmed publisher
Zhang H, Feng L, Wang W, Magness R, Chen D. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-?. J Cell Physiol. 2012;227:146-59 pubmed publisher
Lin W, Rahman N, Lin J, Zhang H, Gou K, Yu W, et al. Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Am J Pathol. 2011;178:1233-44 pubmed publisher
Du S, Sandoval F, Trinh P, Umeda E, Voskuhl R. Estrogen receptor-? ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease. Eur J Immunol. 2011;41:140-50 pubmed publisher
Smejkalova T, Woolley C. Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism. J Neurosci. 2010;30:16137-48 pubmed publisher
Ma Y, Qiao X, Falone A, Reslan O, Sheppard S, Khalil R. Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat. Cell Physiol Biochem. 2010;26:457-70 pubmed publisher
Campbell L, Emmerson E, Davies F, Gilliver S, Krust A, Chambon P, et al. Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med. 2010;207:1825-33 pubmed publisher
Hamilton Burke W, Coleman L, Cummings M, Green C, Holliday D, Horgan K, et al. Phosphorylation of estrogen receptor beta at serine 105 is associated with good prognosis in breast cancer. Am J Pathol. 2010;177:1079-86 pubmed publisher
Dhillon S, Belsham D. Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-? in clonal, immortalized hypothalamic neurons. Int J Obes (Lond). 2011;35:198-207 pubmed publisher
Gilliver S, Emmerson E, Campbell L, Chambon P, Hardman M, Ashcroft G. 17beta-estradiol inhibits wound healing in male mice via estrogen receptor-alpha. Am J Pathol. 2010;176:2707-21 pubmed publisher
Raffetto J, Qiao X, Beauregard K, Khalil R. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010;51:972-81 pubmed publisher
Rossi D, Dai Y, Thomas P, Carrasco G, Doncarlos L, Muma N, et al. Estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta. Psychoneuroendocrinology. 2010;35:1023-33 pubmed publisher
Sobrino A, Oviedo P, Novella S, Laguna Fernandez A, Bueno C, García Pérez M, et al. Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}. J Mol Endocrinol. 2010;44:237-46 pubmed publisher
Liang K, Yang L, Yin C, Xiao Z, Zhang J, Liu Y, et al. Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin. J Biol Chem. 2010;285:935-42 pubmed publisher
Waters E, Mitterling K, Spencer J, Mazid S, McEwen B, Milner T. Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus. Brain Res. 2009;1290:1-11 pubmed publisher
Pedram A, Razandi M, Evinger A, Lee E, Levin E. Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell. 2009;20:3374-89 pubmed publisher
Lu C, Hsieh J, Dun N, Oprea T, Wang P, Luo J, et al. Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats. Gastroenterology. 2009;137:1040-50 pubmed publisher
Leung K, Leung F, Mak N, Tombran Tink J, Huang Y, Wong R. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009;156:626-37 pubmed publisher
Shao R, Nutu M, Weijdegård B, Egecioglu E, Fernandez Rodriguez J, Karlsson Lindahl L, et al. Clomiphene citrate causes aberrant tubal apoptosis and estrogen receptor activation in rat fallopian tube: implications for tubal ectopic pregnancy. Biol Reprod. 2009;80:1262-71 pubmed publisher
Merlo S, Frasca G, Canonico P, Sortino M. Differential involvement of estrogen receptor alpha and estrogen receptor beta in the healing promoting effect of estrogen in human keratinocytes. J Endocrinol. 2009;200:189-97 pubmed publisher
Belcher S, Ma X, Le H. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma. Endocrinology. 2009;150:1112-21 pubmed publisher
Helguero L, Lindberg K, Gardmo C, Schwend T, Gustafsson J, Haldosén L. Different roles of estrogen receptors alpha and beta in the regulation of E-cadherin protein levels in a mouse mammary epithelial cell line. Cancer Res. 2008;68:8695-704 pubmed publisher
Patisaul H, Adewale H, Mickens J. Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis. Behav Brain Res. 2009;196:317-22 pubmed publisher
Sotoca A, van den Berg H, Vervoort J, van der Saag P, Strom A, Gustafsson J, et al. Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells. Toxicol Sci. 2008;105:303-11 pubmed publisher
Sirianni R, Chimento A, Ruggiero C, De Luca A, Lappano R, Ando S, et al. The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line. Endocrinology. 2008;149:5043-51 pubmed publisher
Setlur S, Mertz K, Hoshida Y, Demichelis F, Lupien M, Perner S, et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008;100:815-25 pubmed publisher
Razmara A, Sunday L, Stirone C, Wang X, Krause D, Duckles S, et al. Mitochondrial effects of estrogen are mediated by estrogen receptor alpha in brain endothelial cells. J Pharmacol Exp Ther. 2008;325:782-90 pubmed publisher
Sinkevicius K, Burdette J, Woloszyn K, Hewitt S, Hamilton K, Sugg S, et al. An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology. 2008;149:2970-9 pubmed publisher
Meltser I, Tahera Y, Simpson E, Hultcrantz M, Charitidi K, Gustafsson J, et al. Estrogen receptor beta protects against acoustic trauma in mice. J Clin Invest. 2008;118:1563-70 pubmed publisher
Teng J, Wang Z, Jarrard D, Bjorling D. Roles of estrogen receptor alpha and beta in modulating urothelial cell proliferation. Endocr Relat Cancer. 2008;15:351-64 pubmed publisher
Mersereau J, Levy N, Staub R, Baggett S, Zogovic T, Zogric T, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. 2008;283:49-57 pubmed publisher
Tiwari Woodruff S, Morales L, Lee R, Voskuhl R. Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment. Proc Natl Acad Sci U S A. 2007;104:14813-8 pubmed
Stygar D, Masironi B, Eriksson H, Sahlin L. Studies on estrogen receptor (ER) alpha and beta responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists. J Endocrinol. 2007;194:101-19 pubmed
Silverman J, Koenig J. Evidence for the involvement of ERbeta and RGS9-2 in 17-beta estradiol enhancement of amphetamine-induced place preference behavior. Horm Behav. 2007;52:146-55 pubmed
Walker G, MacLeod K, Williams A, Cameron D, Smyth J, Langdon S. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res. 2007;13:1438-44 pubmed
Bains M, Cousins J, Roberts J. Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon. Exp Neurol. 2007;204:767-76 pubmed
Rayner K, Chen Y, Hibbert B, White D, Miller H, Postel E, et al. NM23-H2, an estrogen receptor beta-associated protein, shows diminished expression with progression of atherosclerosis. Am J Physiol Regul Integr Comp Physiol. 2007;292:R743-50 pubmed
Ohshiro K, Rayala S, Williams M, Kumar R, El Naggar A. Biological role of estrogen receptor beta in salivary gland adenocarcinoma cells. Clin Cancer Res. 2006;12:5994-9 pubmed
Sahlin L, Masironi B, Akerberg S, Eriksson H. Tissue- and hormone-dependent progesterone receptor distribution in the rat uterus. Reprod Biol Endocrinol. 2006;4:47 pubmed
Wieland H, Hechtel N, Faigle M, Neumeister B. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. FEMS Immunol Med Microbiol. 2006;47:296-301 pubmed
Helguero L, Hedengran Faulds M, Förster C, Gustafsson J, Haldosén L. DAX-1 expression is regulated during mammary epithelial cell differentiation. Endocrinology. 2006;147:3249-59 pubmed
O Donnell A, MacLeod K, Burns D, Smyth J, Langdon S. Estrogen receptor-alpha mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen. Endocr Relat Cancer. 2005;12:851-66 pubmed
Taylor R, Cowin P, Couse J, Korach K, Risbridger G. 17beta-estradiol induces apoptosis in the developing rodent prostate independently of ERalpha or ERbeta. Endocrinology. 2006;147:191-200 pubmed
Zhang H, Xie X, Zhu X, Zhu J, Hao C, Lu Q, et al. Stimulatory cross-talk between NFAT3 and estrogen receptor in breast cancer cells. J Biol Chem. 2005;280:43188-97 pubmed
Helguero L, Faulds M, Gustafsson J, Haldosén L. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene. 2005;24:6605-16 pubmed
Ramsey T, Risinger K, Jernigan S, Mattingly K, Klinge C. Estrogen receptor beta isoforms exhibit differences in ligand-activated transcriptional activity in an estrogen response element sequence-dependent manner. Endocrinology. 2004;145:149-60 pubmed
product information
brand :
Tocris
MasterCode :
1494
SKU :
1494/10
product name :
DPN
target :
Estrogen and Related Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
239.27
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
DPN is a highly potent estrogen ER receptor agonist with a 70-fold selectivity over ER (EC50 values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro . Shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus.
extended description :
Highly potent ER agonist
chemical name text :
2,3-bis(4-Hydroxyphenyl)-propionitrile
formula :
C 15 H 13 NO 2
formula text :
C15H13NO2
cas num :
1428-67-7
USD :
190 USD
product details :
Highly potent ER agonist
alt names :
Diarylpropionitrile
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK