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company name :
Tocris Bioscience
product type :
chemical
product name :
MNI-caged-L-glutamate
catalog :
1490/10
quantity :
10 mg (also 50 mg)
price :
250 USD
more info or order :
citations: 61
Reference
Wu M, Minkowicz S, Dumrongprechachan V, Hamilton P, Kozorovitskiy Y. Ketamine Rapidly Enhances Glutamate-Evoked Dendritic Spinogenesis in Medial Prefrontal Cortex Through Dopaminergic Mechanisms. Biol Psychiatry. 2021;89:1096-1105 pubmed publisher
Nuno Perez A, Trusel M, Lalive A, Congiu M, Gastaldo D, Tchenio A, et al. Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula. Neuron. 2021;109:947-956.e5 pubmed publisher
Tazerart S, Mitchell D, Miranda Rottmann S, Araya R. A spike-timing-dependent plasticity rule for dendritic spines. Nat Commun. 2020;11:4276 pubmed publisher
Mitchell D, Martineau E, Tazerart S, Araya R. Probing Single Synapses via the Photolytic Release of Neurotransmitters. Front Synaptic Neurosci. 2019;11:19 pubmed publisher
Obashi K, Matsuda A, Inoue Y, Okabe S. Precise Temporal Regulation of Molecular Diffusion within Dendritic Spines by Actin Polymers during Structural Plasticity. Cell Rep. 2019;27:1503-1515.e8 pubmed publisher
Otopalik A, Pipkin J, Marder E. Neuronal morphologies built for reliable physiology in a rhythmic motor circuit. elife. 2019;8: pubmed publisher
Chopek J, Nascimento F, Beato M, Brownstone R, Zhang Y. Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits. Cell Rep. 2018;25:146-156.e3 pubmed publisher
Hangen E, Cordelières F, Petersen J, Choquet D, Coussen F. Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR. Cell Rep. 2018;24:1001-1012.e3 pubmed publisher
Incontro S, Díaz Alonso J, Iafrati J, Vieira M, Asensio C, Sohal V, et al. The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. Nat Commun. 2018;9:2069 pubmed publisher
Cheriyan J, Sheets P. Altered Excitability and Local Connectivity of mPFC-PAG Neurons in a Mouse Model of Neuropathic Pain. J Neurosci. 2018;38:4829-4839 pubmed publisher
Xiao L, Priest M, Kozorovitskiy Y. Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. elife. 2018;7: pubmed publisher
Athilingam J, Ben Shalom R, Keeshen C, Sohal V, Bender K. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. elife. 2017;6: pubmed publisher
Lu H, Balmer T, Romero G, Trussell L. Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. Neuron. 2017;96:73-80.e4 pubmed publisher
Kiragasi B, Wondolowski J, Li Y, Dickman D. A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation. Cell Rep. 2017;19:2694-2706 pubmed publisher
Goo M, Sancho L, Slepak N, Boassa D, Deerinck T, Ellisman M, et al. Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol. 2017;216:2499-2513 pubmed publisher
Chang J, Parra Bueno P, Laviv T, Szatmari E, Lee S, Yasuda R. CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca2+ Signals during LTP Induction, but Not Maintenance. Neuron. 2017;94:800-808.e4 pubmed publisher
Sigler A, Oh W, Imig C, Altas B, Kawabe H, Cooper B, et al. Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. Neuron. 2017;94:304-311.e4 pubmed publisher
Otopalik A, Sutton A, Banghart M, Marder E. When complex neuronal structures may not matter. elife. 2017;6: pubmed publisher
Zhang R, Li X, Kawakami K, Du J. Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors. Nat Commun. 2016;7:12650 pubmed publisher
Oberlander J, Woolley C. 17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci. 2016;36:2677-90 pubmed publisher
Berlin S, Szobota S, Reiner A, Carroll E, Kienzler M, Guyon A, et al. A family of photoswitchable NMDA receptors. elife. 2016;5: pubmed publisher
Yang S, Tang C, Yang S. The Shaping of Two Distinct Dendritic Spikes by A-Type Voltage-Gated K(+) Channels. Front Cell Neurosci. 2015;9:469 pubmed publisher
Laprell L, Repak E, Franckevicius V, Hartrampf F, Terhag J, Hollmann M, et al. Optical control of NMDA receptors with a diffusible photoswitch. Nat Commun. 2015;6:8076 pubmed publisher
Erlandson M, Manzoni O, Bureau I. The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation. PLoS ONE. 2015;10:e0132008 pubmed publisher
Otmakhov N, Regmi S, Lisman J. Fast Decay of CaMKII FRET Sensor Signal in Spines after LTP Induction Is Not Due to Its Dephosphorylation. PLoS ONE. 2015;10:e0130457 pubmed publisher
Ferreira A, Yousuf H, Dalton S, Sheets P. Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. Front Cell Neurosci. 2015;9:161 pubmed publisher
Harnett M, Magee J, Williams S. Distribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons. J Neurosci. 2015;35:1024-37 pubmed publisher
Nygaard V, Prasmickaite L, Vasiliauskaite K, Clancy T, Hovig E. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Oncoscience. 2014;1:82-94 pubmed
Stephany C, Chan L, Parivash S, Dorton H, Piechowicz M, Qiu S, et al. Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. J Neurosci. 2014;34:11631-40 pubmed publisher
Kamijo T, Hayakawa H, Fukushima Y, Kubota Y, Isomura Y, Tsukada M, et al. Input integration around the dendritic branches in hippocampal dentate granule cells. Cogn Neurodyn. 2014;8:267-76 pubmed publisher
Goddard C, Mysore S, Bryant A, Huguenard J, Knudsen E. Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain. PLoS ONE. 2014;9:e85865 pubmed publisher
Ikrar T, Guo N, He K, Besnard A, Levinson S, Hill A, et al. Adult neurogenesis modifies excitability of the dentate gyrus. Front Neural Circuits. 2013;7:204 pubmed publisher
Go M, To M, Stricker C, Redman S, Bachor H, Stuart G, et al. Four-dimensional multi-site photolysis of caged neurotransmitters. Front Cell Neurosci. 2013;7:231 pubmed publisher
Li Y, Stam F, Aimone J, Goulding M, Callaway E, Gage F. Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2013;110:9106-11 pubmed publisher
Abbas S, Hamade K, Yang E, Nawy S, Smith R, Pettit D. Directional summation in non-direction selective retinal ganglion cells. PLoS Comput Biol. 2013;9:e1002969 pubmed publisher
Apostolides P, Trussell L. Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse. J Neurosci. 2013;33:4768-81 pubmed publisher
Turesson H, Rodríguez Sierra O, PARE D. Intrinsic connections in the anterior part of the bed nucleus of the stria terminalis. J Neurophysiol. 2013;109:2438-50 pubmed publisher
Ferrario C, Goussakov I, Stutzmann G, Wolf M. Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines. PLoS ONE. 2012;7:e40898 pubmed publisher
Callender R, Gameiro A, Pinto A, De Micheli C, Grewer C. Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B. Biochemistry. 2012;51:5486-95 pubmed
Zhang W, Huguenard J, Buckmaster P. Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci. 2012;32:1183-96 pubmed publisher
Dubos A, Combeau G, Bernardinelli Y, Barnier J, Hartley O, Gaertner H, et al. Alteration of synaptic network dynamics by the intellectual disability protein PAK3. J Neurosci. 2012;32:519-27 pubmed publisher
De Biase L, Kang S, Baxi E, Fukaya M, Pucak M, Mishina M, et al. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Neurosci. 2011;31:12650-62 pubmed publisher
Vandenberg R, Handford C, Campbell E, Ryan R, Yool A. Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. Biochem J. 2011;439:333-40 pubmed publisher
Doretto S, Malerba M, Ramos M, Ikrar T, Kinoshita C, De Mei C, et al. Oligodendrocytes as regulators of neuronal networks during early postnatal development. PLoS ONE. 2011;6:e19849 pubmed publisher
Davison I, Ehlers M. Neural circuit mechanisms for pattern detection and feature combination in olfactory cortex. Neuron. 2011;70:82-94 pubmed publisher
Nothmann D, Leinenweber A, Torres Salazar D, Kovermann P, Hotzy J, Gameiro A, et al. Hetero-oligomerization of neuronal glutamate transporters. J Biol Chem. 2011;286:3935-43 pubmed publisher
Earls L, Bayazitov I, Fricke R, Berry R, Illingworth E, Mittleman G, et al. Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome. J Neurosci. 2010;30:15843-55 pubmed publisher
Hammond A, Rodriguez A, Townsend S, Niswender C, Gregory K, Lindsley C, et al. Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chem Neurosci. 2010;1:702-716 pubmed
Tao Z, Rosental N, Kanner B, Gameiro A, Mwaura J, Grewer C. Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101. J Biol Chem. 2010;285:17725-33 pubmed publisher
Xu X, Olivas N, Levi R, Ikrar T, Nenadic Z. High precision and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. J Neurophysiol. 2010;103:2301-12 pubmed publisher
Wood L, Gray N, Zhou Z, Greenberg M, Shepherd G. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. J Neurosci. 2009;29:12440-8 pubmed publisher
Holbro N, Grunditz A, Oertner T. Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses. Proc Natl Acad Sci U S A. 2009;106:15055-60 pubmed publisher
Brill J, Huguenard J. Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation. J Neurosci. 2009;29:7413-23 pubmed publisher
Nikolenko V, Watson B, Araya R, Woodruff A, Peterka D, Yuste R. SLM Microscopy: Scanless Two-Photon Imaging and Photostimulation with Spatial Light Modulators. Front Neural Circuits. 2008;2:5 pubmed publisher
Brill J, Huguenard J. Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit. J Neurosci. 2008;28:13918-28 pubmed publisher
Shankar G, Bloodgood B, Townsend M, Walsh D, Selkoe D, Sabatini B. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007;27:2866-75 pubmed
Araya R, Eisenthal K, Yuste R. Dendritic spines linearize the summation of excitatory potentials. Proc Natl Acad Sci U S A. 2006;103:18799-804 pubmed
Araya R, Jiang J, Eisenthal K, Yuste R. The spine neck filters membrane potentials. Proc Natl Acad Sci U S A. 2006;103:17961-6 pubmed
El Kouhen O, Lehto S, Pan J, Chang R, Baker S, Zhong C, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006;149:761-74 pubmed
Tao Z, Zhang Z, Grewer C. Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. J Biol Chem. 2006;281:10263-72 pubmed
Huang Y, Sinha S, Tanaka K, Rothstein J, Bergles D. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci. 2004;24:4551-9 pubmed
product information
brand :
Tocris
MasterCode :
1490
SKU :
1490/10
product name :
MNI-caged-L-glutamate
target :
Glutamate Receptor Compounds
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
323.3
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MNI-caged-L-glutamate is a form of glutamate linked to a photo-protecting group, 4-methoxy-7-nitroindolinyl (MNI); it rapidly and efficiently releases L-glutamate (Cat. No. 0218) by photolysis (300 - 380 nm excitation) with a quantum yield in the 0.065-0.085 range. It is also suitable for use with two-photon uncaging microscopy (cross-section of 0.06 GM at 730 nm). MNI-caged-L-glutamate is optically compatible with other chromophores used for fluorescence imaging, such as GFP, YFP and most Ca2+ dyes. MNI-caged-L-glutamate is 2.5-fold more efficient at releasing L-glutamate than NI-caged L-glutamate. MNI-caged-L-glutamate is water-soluble, stable at neutral pH, highly resistant to hydrolysis and pharmacologically inactive at neuronal glutamate receptors and transporters (up to mM concentrations). MNI-caged-L-glutamate can be used for in situ studies of fast synaptic glutamate receptors. . View more information regarding MNI-caged-L-glutamate .
extended description :
Stable photoreleaser of L-glutamate
chemical name text :
(S)- -Amino-2,3-dihydro-4-methoxy-7-nitro- -oxo-1H-indole-1-pentanoic acid
formula :
C 14 H 17 N 3 O 6
formula text :
C14H17N3O6
cas num :
295325-62-1
USD :
250 USD
product details :
Stable photoreleaser of L-glutamate
alt names :
4-Methoxy-7-nitroindolinyl-caged- L -glutamate, MNI glutamate
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK