Mithramycin A | Tocris Bioscience 1489/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mithramycin A

catalog :

1489/1

quantity :

1 mg

price :

148 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Huang D, Li T, Wang L, Zhang L, Yan R, Li K, et al. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Res. 2016;26:1112-1130 pubmed publisher
Oh S, Lee S, Jung Y, Lee H, Han H. Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation. Cell Death Dis. 2015;6:e1750 pubmed publisher
Siddesha J, Valente A, Sakamuri S, Gardner J, Delafontaine P, Noda M, et al. Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK. J Cell Physiol. 2014;229:845-55 pubmed publisher
Huang S, Scruggs A, Donaghy J, McEachin R, Fisher A, Richardson B, et al. Prostaglandin E? increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB J. 2012;26:3703-14 pubmed publisher
Corsini E, Zancanella O, Lucchi L, Viviani B, Marinovich M, Galli C. Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes. Gene Regul Syst Bio. 2007;1:207-15 pubmed
Duverger V, Murphy A, Sheehan D, England K, Cotter T, Hayes I, et al. The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF). Br J Cancer. 2004;90:2025-31 pubmed

product information

brand :

Tocris

MasterCode :

1489

SKU :

1489/1

product name :

Mithramycin A

target :

RNA/DNA Polymerase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

95%

observed molecular weight :

1085.16

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

extended description :

Inhibitor of DNA and RNA polymerase

chemical name text :

(1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy- -D-arabino-hexopyranosyl)- -D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl- -D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy- -D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6

formula :

C 52 H 76 O 24

formula text :

C52H76O24

cas num :

18378-89-7

USD :

148 USD

product details :

Inhibitor of DNA and RNA polymerase

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage