product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
Mifepristone
catalog :
1479/100
quantity :
100 mg
price :
96 USD
more info or order :
citations: 22
Reference
Zandieh Z, Amjadi F, Vakilian H, Aflatoonian K, Amirchaghmaghi E, Fazeli A, et al. Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells. Clin Exp Reprod Med. 2018;45:154-162 pubmed publisher
Lee J, Kim T, Kim J, Yoon J, Kim H, Lee K. The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice. Immune Netw. 2016;16:242-8 pubmed publisher
Pinheiro B, Lemos C, Neutzling Kaufmann F, Marques J, da Silva Santos C, Carvalho E, et al. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016;124:222-30 pubmed publisher
Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet J, et al. Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo. EMBO J. 2015;34:1572-88 pubmed publisher
Zarif J, Lamb L, Schulz V, Nollet E, Miranti C. Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase. Oncotarget. 2015;6:6862-76 pubmed
Zimprich A, Garrett L, Deussing J, Wotjak C, Fuchs H, Gailus Durner V, et al. A robust and reliable non-invasive test for stress responsivity in mice. Front Behav Neurosci. 2014;8:125 pubmed publisher
Liu Z, Song C, Wang M, He Y, Xu X, Pan H, et al. Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain. 2014;7:32 pubmed publisher
Krug R, Poshusta T, Skuster K, Berg M, Gardner S, Clark K. A transgenic zebrafish model for monitoring glucocorticoid receptor activity. Genes Brain Behav. 2014;13:478-87 pubmed publisher
Sze C, Lin Y, Lin Y, Hsieh T, Kuo Y, Lin C. The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups. Mediators Inflamm. 2013;2013:628094 pubmed publisher
Shikatani E, Trifonova A, Mandel E, Liu S, Roudier E, Krylova A, et al. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS ONE. 2012;7:e46625 pubmed publisher
Dorey R, Pierard C, Chauveau F, David V, Beracochea D. Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology. 2012;37:2870-80 pubmed publisher
Butts K, Weinberg J, Young A, Phillips A. Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function. Proc Natl Acad Sci U S A. 2011;108:18459-64 pubmed publisher
Kodithuwakku S, Pang R, Ng E, Cheung A, Horne A, Ho P, et al. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest. 2012;92:256-64 pubmed publisher
Liu N, Chakrabarti S, Schnell S, Wessendorf M, Gintzler A. Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal ?- and ?-opioid receptor heterodimerization and female-specific spinal morphine antinociception. J Neurosci. 2011;31:11836-45 pubmed publisher
Luoma J, Kelley B, Mermelstein P. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids. 2011;76:845-55 pubmed publisher
Urbanet R, Pilon C, Calcagno A, Peschechera A, Hubert E, Giacchetti G, et al. Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. J Clin Endocrinol Metab. 2010;95:4037-42 pubmed publisher
Schwendt M, McGinty J. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors. Neuroscience. 2010;168:96-107 pubmed publisher
Zhang X. Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-beta-estradiol and progesterone. Biol Reprod. 2010;82:1037-48 pubmed publisher
Campioni M, Xu M, McGehee D. Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurophysiol. 2009;101:3192-8 pubmed publisher
Mayanagi T, Morita T, Hayashi K, Fukumoto K, Sobue K. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. J Biol Chem. 2008;283:31183-96 pubmed publisher
Wood S, Verhoeven R, Savit A, Rice K, Fischbach P, Woods J. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. Neuropsychopharmacology. 2006;31:2580-90 pubmed
Yang C, Huang C, Hsu K. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci. 2005;25:4288-93 pubmed
product information
brand :
Tocris
MasterCode :
1479
SKU :
1479/100
product name :
Mifepristone
target :
Progesterone Receptor Antagonists
category :
Small Molecules
unit size :
100 mg
purity :
99%
observed molecular weight :
429.6
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Mifepristone is a selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).
extended description :
Progesterone and glucocorticoid receptor antagonist
chemical name text :
(11 ,17 )-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
formula :
C 29 H 35 NO 2
formula text :
C29H35NO2
cas num :
84371-65-3
USD :
96 USD
product details :
Progesterone and glucocorticoid receptor antagonist
alt names :
RU 486, RU 38486
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK