GR 127935 hydrochloride | Tocris Bioscience 1477/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GR 127935 hydrochloride

catalog :

1477/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Li Y, Lucas Osma A, Black S, Bandet M, Stephens M, Vavrek R, et al. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med. 2017;23:733-741 pubmed publisher
Akerman S, Holland P, Lasalandra M, Goadsby P. Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. J Neurosci. 2013;33:14869-77 pubmed publisher
Khatri N, Simpson K, Lin R, Paul I. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl). 2014;231:1191-200 pubmed publisher
Eriksson T, Alvarsson A, Stan T, Zhang X, Hascup K, Hascup E, et al. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol Psychiatry. 2013;18:1096-105 pubmed publisher
Baillie L, Ahn A, Mulligan S. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Neuropharmacology. 2012;63:362-7 pubmed publisher
Masterson C, Durham P. DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons. Headache. 2010;50:1424-39 pubmed publisher
Wei L, Liu Y, Kaneto H, Fanburg B. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010;298:L863-9 pubmed publisher
Morikawa T, Matsuzawa Y, Makita K, Katayama Y. Antimigraine drug, zolmitriptan, inhibits high-voltage activated calcium currents in a population of acutely dissociated rat trigeminal sensory neurons. Mol Pain. 2006;2:10 pubmed

product information

brand :

Tocris

MasterCode :

1477

SKU :

1477/10

product name :

GR 127935 hydrochloride

target :

5-HT1D Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

534.06

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GR 127935 hydrochloride is a potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.

extended description :

Potent and selective 5-HT1B and 5-HT1D antagonist

chemical name text :

N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2 -methyl-4 -(5-methyl-1,2,4-oxadiazol-3-yl)-1,1 -biphenyl-4-carboxamide hydrochloride

formula :

C 29 H 31 N 5 O 3 .HCl

formula text :

C29H31N5O3.HCl

cas num :

148642-42-6

USD :

264 USD

product details :

Potent and selective 5-HT1B and 5-HT1D antagonist

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage