(-)-[3R,4S]-Chromanol 293B | Tocris Bioscience 1475/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(-)-[3R,4S]-Chromanol 293B

catalog :

1475/10

quantity :

10 mg (also 50 mg)

price :

234 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Song L, Bekdash R, Morikawa K, Quejada J, Klein A, Aina Badejo D, et al. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat Cardiovasc Res. 2022;1:142-156 pubmed publisher
Purtell K, Paroder Belenitsky M, Reyna Neyra A, Nicola J, Koba W, Fine E, et al. The KCNQ1-KCNE2 K? channel is required for adequate thyroid I? uptake. FASEB J. 2012;26:3252-9 pubmed publisher
Ma J, Guo L, Fiene S, Anson B, Thomson J, Kamp T, et al. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol. 2011;301:H2006-17 pubmed publisher

image

image 1 :

Cat.No. 1475 - (-)-[3R,4S]-Chromanol 293B C15H20N2O4S CAS No. 163163-24-4

product information

brand :

Tocris

master code :

1475

SKU :

1475/10

product name :

(-)-[3R,4S]-Chromanol 293B

description :

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

target :

Voltage-gated Potassium Channel Blockers

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

324.39

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

(-)-[3 R ,4 S ]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 u M respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 30 u M). . Racemate also available.

extended description :

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

chemical name text :

N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

formula :

C 15 H 20 N 2 O 4 S

formula text :

C15H20N2O4S

cas num :

163163-24-4

USD :

234 USD

product details :

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage