Suramin hexasodium salt | Tocris Bioscience 1472/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Suramin hexasodium salt

catalog :

1472/50

quantity :

50 mg

price :

98 USD

more info or order :

Tocris Bioscience product webpage

citations: 26

Reference
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Mikolajewicz N, Zimmermann E, Willie B, Komarova S. Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair. elife. 2018;7: pubmed publisher
Conley J, Radhakrishnan S, Valentino S, Tantama M. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor. PLoS ONE. 2017;12:e0187481 pubmed publisher
Zierhut M, Dyckhoff S, Masouris I, Klein M, Hammerschmidt S, Pfister H, et al. Role of purinergic signaling in experimental pneumococcal meningitis. Sci Rep. 2017;7:44625 pubmed publisher
Zhang P, Zhang G, Zhou W, Weng S, Yang X, Zhong Y. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells. Sci Rep. 2016;6:28938 pubmed publisher
Yuryev M, Pellegrino C, Jokinen V, Andriichuk L, Khirug S, Khiroug L, et al. In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex. Front Cell Neurosci. 2015;9:500 pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Rosa J, Bos R, Sack G, Fortuny C, Agarwal A, Bergles D, et al. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. elife. 2015;4: pubmed publisher
Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed publisher
Naviaux J, Wang L, Li K, Bright A, Alaynick W, Williams K, et al. Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model. Mol Autism. 2015;6:1 pubmed publisher
Tang W, Szokol K, Jensen V, Enger R, Trivedi C, Hvalby Ø, et al. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 2015;35:3016-21 pubmed publisher
Makris E, Huang B, Hu J, Chen Izu Y, Athanasiou K. Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage. Tissue Eng Part A. 2015;21:884-94 pubmed publisher
Fonseca B, MartÃnez Ãguila A, DÃaz HernÃ¡ndez M, Pintor J. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal. 2015;11:87-93 pubmed publisher
Naviaux J, Schuchbauer M, Li K, Wang L, Risbrough V, Powell S, et al. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Transl Psychiatry. 2014;4:e400 pubmed publisher
Malmersjö S, Rebellato P, Smedler E, Planert H, Kanatani S, Liste I, et al. Neural progenitors organize in small-world networks to promote cell proliferation. Proc Natl Acad Sci U S A. 2013;110:E1524-32 pubmed publisher
Naviaux R, Zolkipli Z, Wang L, Nakayama T, Naviaux J, Le T, et al. Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS ONE. 2013;8:e57380 pubmed publisher
Visovatti S, Hyman M, Bouïs D, Neubig R, McLaughlin V, Pinsky D. Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension. PLoS ONE. 2012;7:e40829 pubmed publisher
Sivaramakrishnan V, Bidula S, Campwala H, Katikaneni D, Fountain S. Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes. J Cell Sci. 2012;125:4567-75 pubmed publisher
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W. ATP release and autocrine signaling through P2X4 receptors regulate ?? T cell activation. J Leukoc Biol. 2012;92:787-94 pubmed publisher
Fritsche G, Nairz M, Libby S, Fang F, Weiss G. Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol. 2012;92:353-9 pubmed publisher
Hazleton J, Berman J, Eugenin E. Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol. 2012;188:4488-95 pubmed publisher
Ibáñez G, Shum D, Blum G, Bhinder B, Radu C, Antczak C, et al. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen. 2012;15:359-71 pubmed
Rodríguez Zayas A, Torrado A, Rosas O, Santiago J, Figueroa J, Miranda J. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. J Mol Neurosci. 2012;46:167-76 pubmed publisher
Thrane A, Rappold P, Fujita T, Torres A, Bekar L, Takano T, et al. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 2011;108:846-51 pubmed publisher
Verma V, Mann A, Costain W, Pontoriero G, Castellano J, Skoblenick K, et al. Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog. J Pharmacol Exp Ther. 2005;315:1228-36 pubmed
Price T, Patwardhan A, Akopian A, Hargreaves K, Flores C. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol. 2004;142:257-66 pubmed

image

image 1 :

Non-selective P2 antagonist

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1472

SKU :

1472/50

product name :

Suramin hexasodium salt

description :

Non-selective P2 antagonist

target :

P2X Receptor Antagonists

unit size :

50 mg

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

1429.15

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Suramin hexasodium salt is a non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels and acts as a competitive 1 2 2 GABAA receptor antagonist. Anticancer, antiviral and antiparasitic agent. . This product may be supplied with a high degree of hydration and some residual NaCl, the amounts of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

product keywords :

Non-Selective P2 antagonists P2X P2Y Uncouples G proteins from receptors heterotrimeric purinoceptors ryanodine receptors ion channels GABAA antagonism P2X Receptors Heterotrimeric G-protein GTPases Purinergic P2Y Receptors Ryanodine Receptors GABAA Receptors 1472,

extended description :

Non-selective P2 antagonist

chemical name text :

8,8 -[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

formula :

C51H34N6Na6O23S6

formula text :

C51H34N6Na6O23S6

cas num :

129-46-4

USD :

USD 2025 :

98 USD

product details :

Non-selective P2 antagonist

more info or order :

Tocris Bioscience product webpage