Orexin A (human, rat, mouse) | Tocris Bioscience 1455/500U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Orexin A (human, rat, mouse)

catalog :

1455/500U

quantity :

500 ug

price :

627 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Forte N, Boccella S, Tunisi L, Fernández Rilo A, Imperatore R, Iannotti F, et al. Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice. Nat Commun. 2021;12:6137 pubmed publisher
Khoo S, McNally G, Clemens K. The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS ONE. 2017;12:e0173967 pubmed publisher
Kim T, Han P. Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors. Exp Neurobiol. 2016;25:307-317 pubmed publisher
Kim M, Park H, Kim S, Choi Y, Bae S, Bae M. Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells. Korean J Physiol Pharmacol. 2015;19:327-34 pubmed publisher
Shu Q, Hu Z, Huang C, Yu X, Fan H, Yang J, et al. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS ONE. 2014;9:e95259 pubmed publisher
Guo Y, Feng P. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. 2012;318:2004-13 pubmed publisher
Lungwitz E, Molosh A, Johnson P, Harvey B, Dirks R, Dietrich A, et al. Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats. Physiol Behav. 2012;107:726-32 pubmed publisher
Moorman D, Aston Jones G. Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences. J Neurosci. 2010;30:15585-99 pubmed publisher
Burdyga G, Varro A, Dimaline R, Thompson D, Dockray G. Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol. 2010;299:G63-9 pubmed publisher
Gompf H, Aston Jones G. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. Brain Res. 2008;1224:43-52 pubmed publisher
Holland P, Akerman S, Goadsby P. Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Pharmacol Exp Ther. 2005;315:1380-5 pubmed

product information

brand :

Tocris

master code :

1455

SKU :

1455/500U

product name :

Orexin A (human, rat, mouse)

description :

Endogenous agonist at OX1 and OX2

target :

Orexin Receptor Agonists

category :

Peptides

unit sizes :

500 ug

purity :

95%

species :

Human, Mouse, Rat

observed molecular weight :

3561.12

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Orexin A (human, rat, mouse) is an endogenous agonist with high affinity at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Orexin A stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Orexin A impairs neurogenesis and hippocampal plasticity in mice. Orexin A improves glucose control and beta cell functions in type 2 diabetic animals.

extended description :

Endogenous agonist at OX1 and OX2

formula :

C 152 H 243 N 47 O 44 S 4

formula text :

C152H243N47O44S4

cas num :

205640-90-0

USD :

627 USD

product details :

Endogenous agonist at OX1 and OX2

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage