GYKI 52466 dihydrochloride | Tocris Bioscience 1454/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GYKI 52466 dihydrochloride

catalog :

1454/10

quantity :

10 mg (also 50 mg)

price :

188 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Bretin S, Louis C, Seguin L, Wagner S, Thomas J, Challal S, et al. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors. PLoS ONE. 2017;12:e0184429 pubmed publisher
Bao H, Sun L, Zhu Y, Ran P, Hu W, Zhu K, et al. Lentinan produces a robust antidepressant-like effect via enhancing the prefrontal Dectin-1/AMPA receptor signaling pathway. Behav Brain Res. 2017;317:263-271 pubmed publisher
Bao H, Ran P, Zhu M, Sun L, Li B, Hou Y, et al. The Prefrontal Dectin-1/AMPA Receptor Signaling Pathway Mediates The Robust and Prolonged Antidepressant Effect of Proteo-β-Glucan from Maitake. Sci Rep. 2016;6:28395 pubmed publisher
Li B, Hou Y, Zhu M, Bao H, Nie J, Zhang G, et al. 3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
Vielma A, Agurto A, Valdes J, Palacios A, Schmachtenberg O. Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. PLoS ONE. 2014;9:e114330 pubmed publisher
Fernandes J, Vieira M, Carreto L, Santos M, Duarte C, Carvalho A, et al. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons. PLoS ONE. 2014;9:e99958 pubmed publisher
Kopach O, Kao S, Petralia R, Belan P, Tao Y, Voitenko N. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn. Pain. 2011;152:912-23 pubmed publisher
Lobb C, Wilson C, Paladini C. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol. 2010;104:403-13 pubmed publisher
Farley S, Apazoglou K, Witkin J, Giros B, Tzavara E. Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm. Int J Neuropsychopharmacol. 2010;13:1207-18 pubmed publisher
Santos S, Luz L, Szucs P, Lima D, Derkach V, Safronov B. Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord. PLoS ONE. 2009;4:e8047 pubmed publisher
Fritsch B, Qashu F, Figueiredo T, Aroniadou Anderjaska V, Rogawski M, Braga M. Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience. 2009;163:415-29 pubmed publisher
Lebrun Julien F, Duplan L, Pernet V, Osswald I, Sapieha P, Bourgeois P, et al. Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. J Neurosci. 2009;29:5536-45 pubmed publisher
Park J, Yaster M, Guan X, Xu J, Shih M, Guan Y, et al. Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain. 2008;4:67 pubmed publisher
Avshalumov M, Patel J, Rice M. AMPA receptor-dependent H2O2 generation in striatal medium spiny neurons but not dopamine axons: one source of a retrograde signal that can inhibit dopamine release. J Neurophysiol. 2008;100:1590-601 pubmed publisher
Lin C, Hilgenberg L, Smith M, Lynch G, Gall C. Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Mol Cell Neurosci. 2008;37:770-80 pubmed publisher
Du J, Creson T, Wu L, Ren M, Gray N, Falke C, et al. The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. J Neurosci. 2008;28:68-79 pubmed publisher
Gerstner B, Gratopp A, Marcinkowski M, Sifringer M, Obladen M, Buhrer C. Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: a novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency. Pediatr Res. 2005;57:771-6 pubmed
Huang Y, Sinha S, Tanaka K, Rothstein J, Bergles D. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci. 2004;24:4551-9 pubmed

product information

brand :

Tocris

master code :

1454

SKU :

1454/10

product name :

GYKI 52466 dihydrochloride

description :

Selective non-competitive AMPA antagonist

target :

AMPA Receptor Antagonists

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

366.24

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GYKI 52466 dihydrochloride is a selective noncompetitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and 50 M for AMPA-, kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells.

extended description :

Selective non-competitive AMPA antagonist

chemical name text :

4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine dihydrochloride

formula :

C 17 H 15 N 3 O 2 .2HCl

formula text :

C17H15N3O2.2HCl

cas num :

2319722-40-0

USD :

188 USD

product details :

Selective non-competitive AMPA antagonist

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage