Formoterol hemifumarate | Tocris Bioscience 1448/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Formoterol hemifumarate

catalog :

1448/10

quantity :

10 mg (also 50 mg)

price :

188 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Koziczak Holbro M, Rigel D, Dumotier B, Sykes D, Tsao J, Nguyen N, et al. Pharmacological characterization of a novel 5-hydroxybenzothiazolone (5-HOB) derived β2-adrenoceptor agonist with functional selectivity for anabolic effects on skeletal muscle resulting in a wider cardiovascular safety window in preclinical studies. J Pharmacol Exp Ther. 2019;: pubmed publisher
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Bacou E, HaurognÃ© K, Allard M, Mignot G, Bach J, HervÃ© J, et al. Î²2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages. Dev Comp Immunol. 2017;76:169-176 pubmed publisher
Lavine J, Farnoodian M, Wang S, Darjatmoko S, Wright L, Gamm D, et al. ?2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 2017;58:299-308 pubmed publisher
Pon C, Lane J, Sloan E, Halls M. The Î²2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J. 2016;30:1144-54 pubmed publisher
Liu Y, Wu S, Wang G, Huang N, Liu C. A long-acting Î²2-adrenergic agonist increases the expression of muscarine cholinergic subtypeâ€‘3 receptors by activating the Î²2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Mol Med Rep. 2015;11:4121-8 pubmed publisher
Lavine J, Sang Y, Wang S, Ip M, Sheibani N. Attenuation of choroidal neovascularization by ?(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 2013;131:376-82 pubmed publisher
Maupoil V, Bronquard C, Freslon J, Cosnay P, Findlay I. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol. 2007;150:899-905 pubmed
Plummer H, Yu Q, Cakir Y, Schuller H. Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. BMC Cancer. 2004;4:93 pubmed

product information

brand :

Tocris

master code :

1448

SKU :

1448/10

product name :

Formoterol hemifumarate

description :

Potent and selective 2 agonist

target :

Adrenergic beta-2 Receptor Agonists

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

402.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Formoterol hemifumarate is a potent, selective and long-acting 2-adrenoceptor agonist. Displays 330-fold selectivity for 2 over 1 receptors (pKd values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD2 = 9.29), and is longer-acting and 100-fold more potent than Salbutamol (Cat. No. 0634).

extended description :

Potent and selective 2 agonist

chemical name text :

( )-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate

formula :

C 19 H 24 N 2 O 4 . C 4 H 4 O 4

formula text :

C19H24N2O4.?C4H4O4

cas num :

43229-80-7

USD :

188 USD

product details :

Potent and selective 2 agonist

alt names :

BD 40A

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage