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company name :
Tocris Bioscience
product type :
chemical
product name :
SKF 81297 hydrobromide
catalog :
1447/10
quantity :
10 mg (also 50 mg)
price :
249 USD
more info or order :
citations: 25
Reference
Dorst M, Tokarska A, Zhou M, Lee K, Stagkourakis S, Broberger C, et al. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun. 2020;11:5113 pubmed publisher
Lin C, Lai H, Chen H, Siew J, Hsiao C, Chang H, et al. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors. Transl Psychiatry. 2019;9:209 pubmed publisher
Saika F, Matsuzaki S, Kobayashi D, Kiguchi N, Kishioka S. Chemokine CXCL1 is responsible for cocaine-induced reward in mice. Neuropsychopharmacol Rep. 2018;38:145-148 pubmed publisher
Podleśny Drabiniok A, Sobska J, de Lera A, Gołembiowska K, Kaminska K, Dolle P, et al. Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons. Sci Rep. 2017;7:13671 pubmed publisher
Guo F, Zhao J, Zhao D, Wang J, Wang X, Feng Z, et al. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 2017;16:1323-1333 pubmed publisher
Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, et al. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017;95:817-833.e4 pubmed publisher
Beckley J, Laguesse S, Phamluong K, Morisot N, Wegner S, Ron D. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci. 2016;36:701-13 pubmed publisher
Pezze M, Marshall H, Cassaday H. Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Psychopharmacology (Berl). 2015;232:2669-80 pubmed publisher
Meunier C, Callebert J, Cancela J, Fossier P. Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex. PLoS ONE. 2015;10:e0120286 pubmed publisher
Södersten E, Feyder M, Lerdrup M, Gomes A, Kryh H, Spigolon G, et al. Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS Genet. 2014;10:e1004574 pubmed publisher
Spulber S, Kilian P, Wan Ibrahim W, Onishchenko N, Ulhaq M, Norrgren L, et al. PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae. PLoS ONE. 2014;9:e94227 pubmed publisher
Parnaudeau S, Dongelmans M, Turiault M, Ambroggi F, Delbes A, Cansell C, et al. Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine. Front Behav Neurosci. 2014;8:35 pubmed publisher
Chen Y, Morganstern I, Barson J, Hoebel B, Leibowitz S. Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons. Alcohol Clin Exp Res. 2014;38:777-86 pubmed publisher
Marley A, Choy R, von Zastrow M. GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. PLoS ONE. 2013;8:e70857 pubmed publisher
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
Hodas J, Nehring A, Höche N, Sweredoski M, Pielot R, Hess S, et al. Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT). Proteomics. 2012;12:2464-76 pubmed publisher
Guha S, Baltazar G, Tu L, Liu J, Lim J, Lu W, et al. Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem. 2012;122:823-33 pubmed publisher
Olianas M, Dedoni S, Onali P. Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex. Neurosignals. 2013;21:61-74 pubmed publisher
Krishnan B, Genzer K, Pollandt S, Liu J, Gallagher J, Shinnick Gallagher P. Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. PLoS ONE. 2011;6:e25639 pubmed publisher
Urizar E, Yano H, Kolster R, Gales C, Lambert N, Javitch J. CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Chem Biol. 2011;7:624-30 pubmed publisher
Li D, Herrera S, Bubula N, Nikitina E, Palmer A, Hanck D, et al. Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation. J Neurochem. 2011;118:237-47 pubmed publisher
Deng J, Rodriguiz R, Hutchinson A, Kim I, Wetsel W, West A. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat Neurosci. 2010;13:1128-36 pubmed publisher
Stramiello M, Wagner J. D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology. 2008;55:871-7 pubmed publisher
Towers S, Hestrin S. D1-like dopamine receptor activation modulates GABAergic inhibition but not electrical coupling between neocortical fast-spiking interneurons. J Neurosci. 2008;28:2633-41 pubmed publisher
Floresco S, Tse M. Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. J Neurosci. 2007;27:2045-57 pubmed
product information
brand :
Tocris
master code :
1447
SKU :
1447/10
product name :
SKF 81297 hydrobromide
description :
D1 agonist
target :
Dopamine D1 and D5 Receptor Agonists
category :
Small Molecules
unit sizes :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
370.67
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SKF 81297 hydrobromide is a dopamine D1-like receptor agonist. Centrally active following systemic administration in vivo .
extended description :
D1 agonist
chemical name text :
( )-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
formula :
C 16 H 16 ClNO 2 .HBr
formula text :
C16H16ClNO2.HBr
cas num :
67287-39-2
USD :
249 USD
product details :
D1 agonist
storage :
Desiccate at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK