Ruthenium Red | Tocris Bioscience 1439/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ruthenium Red

catalog :

1439/100

quantity :

100 mg

price :

126 USD

more info or order :

Tocris Bioscience product webpage

citations: 18

Reference
Battefeld A, Popovic M, de Vries S, Kole M. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep. 2019;26:182-191.e5 pubmed publisher
Perez M, Ponce D, Aranguiz A, Behrens M, Quintanilla R. Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease. Redox Biol. 2018;19:290-300 pubmed publisher
Fernández Fernández D, Cadaveira Mosquera A, Rueda Ruzafa L, Herrera Pérez S, Veale E, Reboreda A, et al. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS ONE. 2018;13:e0199282 pubmed publisher
Ferdek P, Jakubowska M, Nicolaou P, Gerasimenko J, Gerasimenko O, Petersen O. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death Dis. 2017;8:e2640 pubmed publisher
Seedhom M, Hickman H, Wei J, David A, Yewdell J. Protein Translation Activity: A New Measure of Host Immune Cell Activation. J Immunol. 2016;197:1498-506 pubmed publisher
Merino B, Quesada I, HernÃ¡ndez Cascales J. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS ONE. 2015;10:e0132884 pubmed publisher
Shi H, Liu C, Ding L, Zheng Y, Fei X, Lu L, et al. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol. 2015;21:4852-63 pubmed publisher
Son G, Yang Y, Park W, Chang I, Shin D. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res. 2015;94:473-81 pubmed publisher
Lee W, Leddy H, Chen Y, Lee S, Zelenski N, McNulty A, et al. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A. 2014;111:E5114-22 pubmed publisher
Nesuashvili L, Hadley S, Bahia P, Taylor Clark T. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol. 2013;83:1007-19 pubmed publisher
Boychuk C, Zsombok A, Tasker J, Smith B. Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons. Front Neurosci. 2013;7:3 pubmed publisher
Albert E, Bec J, Desmadryl G, Chekroud K, Travo C, Gaboyard S, et al. TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. J Neurophysiol. 2012;107:3227-34 pubmed publisher
Kaszas K, Keller J, Coddou C, Mishra S, Hoon M, Stojilkovic S, et al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012;340:152-60 pubmed publisher
Li J, Kanju P, Patterson M, Chew W, Cho S, Gilmour I, et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect. 2011;119:784-93 pubmed publisher
Giordano G, White C, Mohar I, Kavanagh T, Costa L. Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells. Toxicol Sci. 2007;100:433-44 pubmed
Jacques Fricke B, Seow Y, Gottlieb P, Sachs F, Gomez T. Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. J Neurosci. 2006;26:5656-64 pubmed
Melis M, Perra S, Muntoni A, Pillolla G, Lutz B, Marsicano G, et al. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci. 2004;24:10707-15 pubmed
Moran T, Colmers W, Smith P. Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. J Neurophysiol. 2004;92:3266-75 pubmed

product information

brand :

Tocris

master code :

1439

SKU :

1439/100

product name :

Ruthenium Red

description :

Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels

target :

Cav2.x Channel Blockers

category :

Small Molecules

unit sizes :

100 mg

observed molecular weight :

786.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ruthenium Red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.

extended description :

Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels

chemical name text :

Ammoniated ruthenium oxychloride

formula :

H 42 N 14 O 2 Ru 3 Cl 6

formula text :

H42N14O2Ru3Cl6

cas num :

11103-72-3

USD :

126 USD

product details :

Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage