D609 | Tocris Bioscience 1437/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

D609

catalog :

1437/10

quantity :

10 mg (also 50 mg)

price :

172 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher
Sovadinova I, Babica P, BÃ¶ke H, Kumar E, Wilke A, Park J, et al. Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. PLoS ONE. 2015;10:e0124454 pubmed publisher
Navratil A, Brummett A, Bryan J, Woolard M. Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases. Infect Immun. 2014;82:3299-311 pubmed publisher
Pastor A, Farre M, Fito M, Fernandez Aranda F, de la Torre R. Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res. 2014;55:966-77 pubmed publisher
Upham B, Park J, Babica P, Sovadinova I, Rummel A, Trosko J, et al. Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems. Environ Health Perspect. 2009;117:545-51 pubmed publisher

product information

brand :

Tocris

master code :

1437

SKU :

1437/10

product name :

D609

description :

Selective PC-PLC inhibitor

target :

Phospholipase Inhibitors

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

266.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 M); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFN -induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .

extended description :

Selective PC-PLC inhibitor

chemical name text :

O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate

formula :

C 11 H 15 OS 2 K

formula text :

C11H15OS2K

cas num :

83373-60-8

USD :

172 USD

product details :

Selective PC-PLC inhibitor

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage