product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SQ 22536
catalog :
1435/10
quantity :
10 mg (also 50 mg)
price :
189 USD
more info or order :
citations: 12
Reference
Schnúr A, Premchandar A, Bagdany M, Lukacs G. Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep. 2019;9:12706 pubmed publisher
Costa L, Sardone L, Bonaccorso C, D Antoni S, Spatuzza M, Gulisano W, et al. Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome. Front Mol Neurosci. 2018;11:353 pubmed publisher
Olesen E, Moeller H, Assentoft M, MacAulay N, Fenton R. The vasopressin type 2 receptor and prostaglandin receptors EP2 and EP4 can increase aquaporin-2 plasma membrane targeting through a cAMP-independent pathway. Am J Physiol Renal Physiol. 2016;311:F935-F944 pubmed publisher
Liu C, Zhu P, Wang W, Li W, Shu Q, Chen Z, et al. Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. Mol Cell Endocrinol. 2016;424:118-27 pubmed publisher
Wang W, Guo C, Zhu P, Lu J, Li W, Liu C, et al. Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition. Sci Signal. 2015;8:ra106 pubmed publisher
Du Y, Cramer M, Lee C, Tang J, Muthusamy A, Antonetti D, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015;29:2194-204 pubmed publisher
Tang F, Lane S, Korsak A, Paton J, Gourine A, Kasparov S, et al. Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun. 2014;5:3284 pubmed publisher
Tao Y, Pan M, Liu S, Fang F, Lu R, Lu C, et al. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. PLoS ONE. 2013;8:e71441 pubmed publisher
Babu P, Si H, Fu Z, Zhen W, Liu D. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. J Nutr. 2012;142:724-30 pubmed publisher
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed publisher
Conway Morris A, Kefala K, Wilkinson T, Dhaliwal K, Farrell L, Walsh T, et al. C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med. 2009;180:19-28 pubmed publisher
Bhanu N, Lee Y, Oneal P, Gantt N, Aerbajinai W, Noel P, et al. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. Biochim Biophys Acta. 2008;1782:504-10 pubmed publisher
product information
brand :
Tocris
master code :
1435
SKU :
1435/10
product name :
SQ 22536
description :
Adenylyl cyclase inhibitor
target :
Adenylyl Cyclase Inhibitors
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
205.22
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SQ 22536 is an inhibitor of adenylyl cyclase (IC50 = 1.4 u M). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Cell permeable.
extended description :
Adenylyl cyclase inhibitor
chemical name text :
9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
formula :
C 9 H 11 N 5 O
formula text :
C9H11N5O
cas num :
17318-31-9
USD :
180
USD 2023 :
189 USD
product details :
Adenylyl cyclase inhibitor
storage :
Store at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK