product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1427/10
catalog :
1427/10
quantity :
10 mg (also 50 mg)
price :
189 USD
more info or order :
citations: 14
Reference
Matsui A, Alvarez V. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep. 2018;23:3852-3863 pubmed publisher
Gasull Camós J, Martínez Torres S, Tarrés Gatius M, Ozaita A, Artigas F, Castañé A. Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex. Neuropharmacology. 2018;139:41-51 pubmed publisher
Munari L, Provensi G, Passani M, Galeotti N, Cassano T, Benetti F, et al. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Int J Neuropsychopharmacol. 2015;18:pyv045 pubmed publisher
Phelps C, Mitchell E, Nutt D, Marston H, Robinson E. Psychopharmacological characterisation of the successive negative contrast effect in rats. Psychopharmacology (Berl). 2015;232:2697-709 pubmed publisher
Jury N, McCormick B, Horseman N, Benoit S, Gregerson K. Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation. PLoS ONE. 2015;10:e0117339 pubmed publisher
Nolan T, Geffert L, Kolber B, Madura J, Surratt C. Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci. 2014;5:784-92 pubmed publisher
Jiménez Sánchez L, Campa L, Auberson Y, Adell A. The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression. Neuropsychopharmacology. 2014;39:2673-80 pubmed publisher
Stuart S, Butler P, Munafò M, Nutt D, Robinson E. A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology. 2013;38:1625-35 pubmed publisher
Morecroft I, White K, Caruso P, Nilsen M, Loughlin L, Alba R, et al. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Mol Ther. 2012;20:1516-28 pubmed publisher
Hutchinson A, Deng J, Aryal D, Wetsel W, West A. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology. 2012;37:321-37 pubmed publisher
Murray K, Nakae A, Stephens M, Rank M, D Amico J, Harvey P, et al. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med. 2010;16:694-700 pubmed publisher
Morecroft I, Pang L, Baranowska M, Nilsen M, Loughlin L, Dempsie Y, et al. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovasc Res. 2010;85:593-603 pubmed publisher
Maciag D, Coppinger D, Paul I. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Brain Res. 2006;1125:171-5 pubmed
Maciag D, Simpson K, Coppinger D, Lu Y, Wang Y, Lin R, et al. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology. 2006;31:47-57 pubmed
product information
master code :
1427
SKU :
1427/10
product name :
Citalopram hydrobromide
unit size :
10 mg (also 50 mg)
description :
Highly potent and selective 5-HT uptake inhibitor
target :
5-HT Transporter Inhibitors
category :
Small Molecules
purity :
99%
observed molecular weight :
405.31
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC50 values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.
top caption :
Highly potent and selective 5-HT uptake inhibitor
extended description :
Highly potent and selective 5-HT uptake inhibitor
chemical name text :
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
formula :
C20H21FN2O.HBr
formula text :
C20H21FN2O.HBr
cas num :
59729-32-7
USD :
189 USD
product details :
Highly potent and selective 5-HT uptake inhibitor
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK