(S)-(+)-Dimethindene maleate | Tocris Bioscience 1425 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(S)-(+)-Dimethindene maleate

catalog :

1425

quantity :

10 mg (also 50 mg)

price :

182 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, et al. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell. 2019;179:687-702.e18 pubmed publisher
Xu J, Yu L, Guo J, Xiang J, Zheng Z, Gao D, et al. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Res Ther. 2019;10:193 pubmed publisher
Li H, Zhao C, Xu J, Xu Y, Cheng C, Liu Y, et al. Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell. 2019;10:20-30 pubmed publisher
Du Y, Wang T, Xu J, Zhao C, Li H, Fu Y, et al. Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg-/- mice. Protein Cell. 2019;10:31-42 pubmed publisher
Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed publisher
Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor M, et al. Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. Urology. 2010;75:862-7 pubmed publisher

product information

brand :

Tocris

master code :

1425

SKU :

1425/10

product name :

(S)-(+)-Dimethindene maleate

description :

Selective M2 antagonist

target :

mAChR M2 Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

408.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.

catalog number base :

1425

product keywords :

H1 antagonists M2 muscarinic Receptors Histamine Acetylcholine ACh histaminergic M2 Receptors Histamine H1 Receptors Stem Cell Reprogramming 1425,

extended description :

Selective M2 antagonist

chemical name text :

N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate

formula :

C 20 H 24 N 2 .C 4 H 4 O 4

formula text :

C20H24N2.C4H4O4

cas num :

136152-65-3

2020 USD :

173

2021 USD :

182 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage