1422/10 | Tocris Bioscience 1422/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1422/10

catalog :

1422/10

quantity :

10 mg (also 50 mg)

price :

137 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
McCully M, Collins P, Hughes T, Thomas C, Billen J, O Donnell V, et al. Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol. 2015;195:96-104 pubmed publisher
Laube M, Kimpel S, Dietl P, Thome U, Wittekindt O. Benzimidazolones enhance the function of epithelial Na? transport. Br J Pharmacol. 2013;168:1329-40 pubmed publisher
Hirota C, McKay D. Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener. Br J Pharmacol. 2009;156:1085-97 pubmed publisher
MacVinish L, Cope G, Ropenga A, Cuthbert A. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. Br J Pharmacol. 2007;150:1055-65 pubmed
Fioretti B, Pietrangelo T, Catacuzzeno L, Franciolini F. Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. Am J Physiol Cell Physiol. 2005;289:C89-96 pubmed

product information

master code :

1422

SKU :

1422/10

product name :

DCEBIO

unit size :

10 mg (also 50 mg)

description :

Activates Cl- conductance and hKCa3.1 channels

target :

CFTR Activators

category :

Small Molecules

purity :

99%

observed molecular weight :

231.08

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DCEBIO is a stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

top caption :

Activates Cl- conductance and hKCa3.1 channels

extended description :

Activates Cl- conductance and hKCa3.1 channels

chemical name text :

5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

formula :

C9H8Cl2N2O

formula text :

C9H8Cl2N2O

cas num :

60563-36-2

USD :

137 USD

product details :

Activates Cl- conductance and hKCa3.1 channels

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage